The following program
presents principles designed
00:00:01.98\00:00:03.03
to promote good health
and is not intended to take
00:00:03.04\00:00:05.57
the place of
personalized professional care.
00:00:05.58\00:00:08.59
The opinions and ideas expressed
are those of the speaker.
00:00:08.60\00:00:12.02
Viewers are encouraged to
draw their own conclusions
00:00:12.03\00:00:14.41
about the information presented.
00:00:14.42\00:00:16.18
Hello. I am Dr. Emerson,
00:00:36.52\00:00:38.65
Medical Director at
Eden Valley Lifestyle Center.
00:00:38.66\00:00:42.02
I am here to talk to you today
about fever and immune system.
00:00:42.03\00:00:46.34
We want to learn about
the powerful immune stimulant
00:00:46.35\00:00:49.82
effect produced by
fever. Also we're going to look
00:00:49.83\00:00:53.49
at hyperthermy
which is an artificial way
00:00:53.50\00:00:55.79
of producing or reproducing
00:00:55.80\00:00:57.28
these beneficial
effects of fever.
00:00:57.29\00:01:00.70
We're gonna review
some of the rationale
00:01:00.71\00:01:02.54
behind fever treatments.
And then we'll conclude
00:01:02.55\00:01:05.33
with how it was
been used in the past
00:01:05.34\00:01:07.67
and how it can be used,
and is being used today.
00:01:07.68\00:01:11.40
At Eden Valley we
work at strengthening
00:01:11.41\00:01:14.14
the immune system
to help turn it on.
00:01:14.15\00:01:17.84
And also strengthen it
in order to help people
00:01:17.85\00:01:20.64
in their fight against
cancers. Well, first question
00:01:20.65\00:01:23.75
I'd like to ask though is
can a depress immune system
00:01:23.76\00:01:26.63
cause cancers or allow to
develop in the first place?
00:01:26.64\00:01:30.71
And if this is
true then strengthening
00:01:30.72\00:01:33.76
or stimulating the immune system
00:01:33.77\00:01:36.28
should be helpful
for cancer patients.
00:01:36.29\00:01:39.32
We're gonna be
looking at the work
00:01:39.33\00:01:40.83
of Dr. Denise Prickett
taken mainly from biography
00:01:40.84\00:01:45.03
by Nelson in 1998 as a
source of some of the material
00:01:45.04\00:01:50.43
on his work regarding lymphomas.
00:01:50.44\00:01:54.37
Dr. Prickett was
actually raised in England.
00:01:54.38\00:01:58.83
In his college years
he gave his heart to Jesus
00:01:58.84\00:02:01.77
and felt call to go to
Africa under the employment
00:02:01.78\00:02:05.44
of the government
there to work as a surgeon.
00:02:05.45\00:02:09.43
Around 1957 he was
presented with a small boy,
00:02:09.44\00:02:13.44
a five year old boy,
who had the swellings
00:02:13.45\00:02:15.49
in his upper jaw, his lower jaw
00:02:15.50\00:02:19.37
and it was obviously
cancerous, they did a biopsy,
00:02:19.38\00:02:23.20
it showed a small
round cell sarcoma,
00:02:23.21\00:02:25.31
very malignant form of cancer.
They found that it could affect
00:02:25.32\00:02:30.37
the eye, the jaw, the abdomen,
and the kidney, the bone
00:02:30.38\00:02:33.30
or combinations of all of those.
They found that it occurred
00:02:33.31\00:02:37.49
in children of
ages two to twelve,
00:02:37.50\00:02:39.59
peak existence was
around eight years of age.
00:02:39.60\00:02:43.19
And at that time
there was nothing
00:02:43.20\00:02:45.21
they could do for
it, it was lethal.
00:02:45.22\00:02:49.81
Well, he wanted to help,
characterize this lymphoma,
00:02:49.82\00:02:55.68
so he took
trips all over Africa.
00:02:55.69\00:02:58.02
And he plotted the distribution
00:02:58.03\00:02:59.71
of where this
lymphoma was found.
00:02:59.72\00:03:01.88
And he found
something interesting
00:03:01.89\00:03:03.19
that it was distributed
in areas that had 20 inches
00:03:03.20\00:03:08.88
of rainfall or more.
And temperatures that never
00:03:08.89\00:03:12.75
dropped below 60
degrees Fahrenheit.
00:03:12.76\00:03:16.02
Well, this was important because
it matched the description
00:03:16.03\00:03:21.16
or the distribution
of sleeping sickness
00:03:21.17\00:03:23.50
which is a parasitic disease
spread by the tsetse flies.
00:03:23.51\00:03:27.10
It also spread, it
fit the distribution
00:03:27.11\00:03:30.14
of the yellow
fever which was a virus
00:03:30.15\00:03:33.21
spread by the mosquito.
It also fit the distribution
00:03:33.22\00:03:38.48
of O'nyong'nyong
fever or break bone fever
00:03:38.49\00:03:42.38
which is of another viral
diseases spread by the mosquito.
00:03:42.39\00:03:46.20
And it fit the
distribution of malaria,
00:03:46.21\00:03:48.50
which is a parasitic
disease spread by the mosquito.
00:03:48.51\00:03:52.71
Well, with this distribution,
the question arose,
00:03:52.72\00:03:55.54
could this lymphoma
be caused by a virus
00:03:55.55\00:03:58.75
also spread by a mosquito?
Since it was only found
00:03:58.76\00:04:02.25
in the areas that the mosquitoes
00:04:02.26\00:04:04.08
were spreading
malaria and these viruses.
00:04:04.09\00:04:07.16
Well, to answer the
question we want to go back
00:04:07.17\00:04:09.14
in history a bit, and find out
00:04:09.15\00:04:12.10
where our understanding
of viruses came from.
00:04:12.11\00:04:16.50
And then ask the question,
00:04:16.51\00:04:17.52
can a virus
indeed cause cancers?
00:04:17.53\00:04:20.80
Well, our understanding
of viruses actually occurred
00:04:20.81\00:04:23.26
in the 1800s,
with Louis Pasteur.
00:04:23.27\00:04:27.24
When he was
developing the anthrax vaccine,
00:04:27.25\00:04:29.92
he could look under the
microscope and he could see
00:04:29.93\00:04:32.26
the bacteria in the microscope.
But later when he was developing
00:04:32.27\00:04:37.96
the rabies
vaccine, he could not see
00:04:37.97\00:04:41.05
the infecting organism under
the microscope and he said that
00:04:41.06\00:04:46.70
it must be caused by
something infinitesimally small.
00:04:46.71\00:04:51.09
Well, we know today
that it was actually caused
00:04:51.10\00:04:52.89
by the rabies
virus, now which of course
00:04:52.90\00:04:57.18
you can see under
a light microscope.
00:04:57.19\00:04:59.67
In 1892, Ivanowski identified
a Tobacco Mosaic Virus,
00:04:59.68\00:05:06.63
which caused cancer.
The way he discovered
00:05:06.64\00:05:11.04
that it was a
virus, or caused by virus,
00:05:11.05\00:05:14.40
was he would
take the tobacco leaf
00:05:14.41\00:05:16.84
that was
infected with this virus,
00:05:16.85\00:05:19.34
crushed it up, add some
water, and get the solution,
00:05:19.35\00:05:22.00
and then he would
filter the solution
00:05:22.01\00:05:24.14
through porcelain
filter. Now the porcelain filter
00:05:24.15\00:05:26.37
will take out all
bacteria in all cells,
00:05:26.38\00:05:29.79
but will not take out
viruses. These porcelain filters
00:05:29.80\00:05:34.23
can still be purchased
today at camping stores
00:05:34.24\00:05:36.75
that used to filter water
for campers very effective
00:05:36.76\00:05:40.28
in stopping bacterial
and parasitic diseases.
00:05:40.29\00:05:45.24
So he would trans...transmit
this fluid and pass it through
00:05:45.25\00:05:49.63
a porcelain filter.
And then he would take
00:05:49.64\00:05:51.63
the....this fluid and
inoculate another tobacco plant
00:05:51.64\00:05:56.50
and the tobacco
plant will develop
00:05:56.51\00:05:58.37
this tobacco leaf diseases.
00:05:58.38\00:06:02.19
And again it was
spread by something
00:06:03.98\00:06:05.53
that could not be
seen under the microscope.
00:06:05.57\00:06:08.22
And in, excuse me in
1908, excuse me 1898 Serrano
00:06:08.23\00:06:14.63
discovered that a
microscopically invisible
00:06:14.64\00:06:17.47
agent could also
transmit cancer in animals.
00:06:17.48\00:06:22.93
He took some blood from a
rabbit that had a fatal myxomas,
00:06:22.94\00:06:31.32
and he passed that
through a porcelain filter.
00:06:31.33\00:06:34.98
Took out again all the cells,
all the bacteria from the blood,
00:06:34.99\00:06:40.53
he just had fine, a
solution and with that solution
00:06:40.54\00:06:43.59
that cell free solution
inoculate another rabbit
00:06:43.60\00:06:47.48
and induced a
cancer in that new rabbit.
00:06:47.49\00:06:52.23
And again this the
way the fatal myxomas
00:06:52.24\00:06:55.04
were transmittedm from domestic
rabbit to domestic rabbit.
00:06:55.05\00:06:59.18
In 1907 Merrick of Germany,
00:06:59.19\00:07:02.18
he described a
lymphoid cancer in chickens,
00:07:02.19\00:07:05.48
it was highly infectious
00:07:05.49\00:07:06.54
and he presumed it
was due to a virus.
00:07:06.55\00:07:10.51
In 1908 Elliman in
bank of Copenhagen,
00:07:10.52\00:07:14.08
they took the blood
of the leukemic chicken.
00:07:14.09\00:07:16.55
They filtered it again through
one of these porcelain filters,
00:07:16.56\00:07:19.65
taking out all the
cells, took the fluid inoculated
00:07:19.66\00:07:23.10
a healthy chicken
and that healthy chicken
00:07:23.11\00:07:25.44
also developed leukemia.
00:07:25.45\00:07:28.40
A leukemia being
spread by a virus.
00:07:28.41\00:07:32.03
In 1911 Peyton Rous, New
York RockeFeller Institute,
00:07:32.04\00:07:35.77
transmitted a chicken
sarcoma. This is a solid tumor
00:07:35.78\00:07:40.93
from healthy fowl
two healthy fowls using
00:07:40.94\00:07:43.94
a again a cell free
filtrate taking the blood
00:07:43.95\00:07:47.10
of a sick chicken
when they had sarcoma
00:07:47.11\00:07:51.93
passing it through the
filter taking it all the cells
00:07:51.94\00:07:54.40
and injecting that
filter fluid into a healthy fowl
00:07:54.41\00:07:58.83
and inducing
the sarcoma as well.
00:07:58.84\00:08:02.62
In 1932 Richard Shope,
at the Rockefeller Institute
00:08:02.63\00:08:06.04
of Princeton
transmitted a rabbit fibroma
00:08:06.05\00:08:09.37
with a cell free filtrate.
And then in 1936, John Bittner,
00:08:09.38\00:08:15.95
he described a
mouse breast cancer,
00:08:15.96\00:08:18.06
that could have actually
transmitted to a nursing
00:08:18.07\00:08:22.13
female mice who later
developed the breast cancer.
00:08:22.14\00:08:26.70
All these instances of
cancers being transferred
00:08:26.71\00:08:28.78
from one animal
to another implicated
00:08:28.79\00:08:31.35
an infectious
virus transmission.
00:08:31.36\00:08:34.82
Where they ever
able to see the virus?
00:08:34.83\00:08:38.43
It wasn't until 1945
when the electron microscope
00:08:38.44\00:08:41.80
was introduced that the
first, the first viruses
00:08:41.81\00:08:44.96
could actually be clearly seen.
00:08:44.97\00:08:48.38
Following this in 1946,
Claude, Porter and Pickels,
00:08:48.39\00:08:52.44
examined the Rous
sarcoma which is a cancer,
00:08:52.45\00:08:57.06
they looked at the
cells with electron microscope
00:08:57.07\00:08:59.53
and they
reported dense particles
00:08:59.54\00:09:01.68
in the cytoplasm of the
cells. And these are suspected
00:09:01.69\00:09:04.91
to be a virus
causing the cancer.
00:09:04.92\00:09:09.16
Well, then in 1956,
Anthony Epstein definitely
00:09:09.17\00:09:13.99
identified this
tiny 70-millimicron Rous
00:09:14.00\00:09:17.85
sarcoma particles in
the Rous sarcoma cells.
00:09:17.86\00:09:22.55
And this was a definite
proof that Rous sarcoma virus
00:09:22.56\00:09:26.50
was indeed causing the sarcoma
or the cancer in animals.
00:09:26.51\00:09:30.72
So we now had
visible proof that viruses
00:09:30.73\00:09:34.21
could cause cancers in
animals. In 1957 Stewart Netty,
00:09:34.22\00:09:41.98
at the National
Institute of Health,
00:09:41.99\00:09:43.64
they propagated a
prodded tumor virus
00:09:43.65\00:09:46.33
in a tissue culture
which induced a variety
00:09:46.34\00:09:49.66
of tumors in mice,
rats, and hamsters.
00:09:49.67\00:09:53.06
So by 1962, it was
definitely established
00:09:53.07\00:09:57.10
that you could
indeed cause cancers
00:09:57.11\00:09:59.28
and transmit cancers
from animal to animal
00:09:59.29\00:10:02.73
with cell free
filtrates that is viruses.
00:10:02.74\00:10:08.93
Now with the
distribution of this lymphoma,
00:10:08.94\00:10:11.81
this human cancer in Africa,
00:10:11.82\00:10:15.65
the thought was
could this human lymphoma
00:10:15.66\00:10:18.13
be transmitted by a virus also?
Nobody as yet had demonstrated
00:10:18.14\00:10:24.34
that a human virus
could be transmitted
00:10:24.35\00:10:26.87
from person to person.
And so every one was anxious
00:10:26.88\00:10:30.80
to be the first to
demonstrate the transmission
00:10:30.81\00:10:32.73
of a human cancer
from one person to another.
00:10:32.74\00:10:36.45
Well, there are some
more evidence that came up
00:10:36.46\00:10:39.10
in Zanzibar and Kinshasa
which also tended to indicate
00:10:39.11\00:10:44.77
a viral
transmission of this lymphoma.
00:10:44.78\00:10:49.47
They found that in
Zanzibar and Kinshasa,
00:10:49.48\00:10:52.55
nobody there
developed the lymphoma.
00:10:52.56\00:10:55.66
And yet they had rainfall
that was over 20 inches a year,
00:10:55.67\00:11:00.48
and temperatures that
never fell below 60 degrees
00:11:00.49\00:11:03.29
Fahrenheit which
were both the conditions
00:11:03.30\00:11:05.45
for developing the lymphoma.
00:11:05.46\00:11:06.79
So if it was just the weather
issue you would have expected
00:11:06.80\00:11:10.13
the lymphoma to be
present in these two countries.
00:11:10.14\00:11:14.08
But what they found was
that these were the only two
00:11:14.09\00:11:16.11
countries in Africa
that had eradicated malaria,
00:11:16.12\00:11:19.90
by spraying of the water
and are killing the mosquitoes.
00:11:19.91\00:11:24.44
And so, they're now showing
that there seem to be a direct
00:11:24.45\00:11:27.97
relationship between
the incidence and prevalence
00:11:27.98\00:11:30.56
and intensity of malaria
and the incidence of lymphomas.
00:11:30.57\00:11:37.91
Again this was pointing
to appear to be an infectious
00:11:37.92\00:11:41.18
agent causing lymphomas
being spread by mosquitoes.
00:11:41.19\00:11:45.30
In 1964, Dr. Prickett
was able to grow tumor cells
00:11:45.31\00:11:53.57
from these Burkett's
lymphomas. And in these cells,
00:11:53.58\00:11:58.39
he was able to
see viral particles
00:11:58.40\00:12:01.36
that looked like herpes virus.
00:12:01.37\00:12:03.83
They looked like the
herpes virus morphology.
00:12:03.84\00:12:07.59
He called it the
Epstein-Barr virus
00:12:07.60\00:12:10.73
which we are
familiar with today.
00:12:10.74\00:12:13.91
They then found
that our children
00:12:13.92\00:12:16.53
with Burkett's
lymphoma had antibodies
00:12:16.54\00:12:19.16
to Epstein-Barr
virus, showing that they all
00:12:19.17\00:12:22.30
being exposed to the virus.
This was concluding evidence
00:12:22.31\00:12:26.76
that the virus did
indeed caused the cancer.
00:12:26.77\00:12:30.48
Then in 1964, they
ran into a problem.
00:12:30.49\00:12:34.97
They found that 85
percent of all healthy Americans
00:12:34.98\00:12:39.29
also had antibodies
to Epstein-Barr virus
00:12:39.30\00:12:42.25
but they had no
lymphoma. How could this be?
00:12:42.26\00:12:46.41
What was it, in
other words that triggered
00:12:46.42\00:12:49.22
this Epstein-Barr virus
to instead of just causing
00:12:49.23\00:12:55.56
asymptomatic disease in
healthy Americans to going
00:12:55.57\00:12:59.61
into lymphomas
in these Africans.
00:12:59.62\00:13:04.27
Well, in 1967, they
learned something helpful,
00:13:04.28\00:13:11.64
Tony Epstein's young
technician Elaine Hutkin
00:13:11.65\00:13:16.34
became ill with
fever. She got a soar throat
00:13:16.35\00:13:19.61
and large lymph
nodes in the neck.
00:13:19.62\00:13:21.96
She later got a rash,
she is seen by a doctor,
00:13:21.97\00:13:25.62
they got
antibodies before and after
00:13:25.63\00:13:30.48
in her blood at the
lab. And the doctor diagnosed
00:13:30.49\00:13:35.39
her with mononucleosis.
Tony Epstein found
00:13:35.40\00:13:40.18
that her antibodies
had been negative prior
00:13:40.19\00:13:42.92
to this infection
and had become positive.
00:13:42.93\00:13:46.36
And they had just now
seen what an acute infection
00:13:46.37\00:13:50.44
of Epstein-Barr
virus caused in an adult,
00:13:50.45\00:13:54.58
and it was mononucleosis.
And doctors then confirmed
00:13:54.59\00:13:58.85
that this indeed
was the etiologic agent
00:13:58.86\00:14:02.25
from mononucleosis,
they tested hundreds
00:14:02.26\00:14:05.30
of college students
and found that before
00:14:05.31\00:14:09.80
being infected
with mononucleosis,
00:14:09.81\00:14:12.70
their Epstein-Barr
virus tests were negative.
00:14:12.71\00:14:16.34
And then after this
case of mononucleosis
00:14:16.35\00:14:20.42
their
antibodies become positive.
00:14:20.43\00:14:23.62
Later it was learned
that Epstein-Barr virus,
00:14:23.63\00:14:26.47
if it's acquired in
childhood goes unnoticed
00:14:26.48\00:14:29.68
in healthy American
children. If on the other hand
00:14:29.69\00:14:33.47
Epstein-Barr virus
is acquired as an adult
00:14:33.48\00:14:36.42
or even a teenager it
produces mononucleosis.
00:14:36.43\00:14:40.76
And this childhood inoculations
were accounted for 85 percent
00:14:40.77\00:14:44.14
of the positive
Epstein-Barr virus
00:14:44.15\00:14:45.70
prevalence in America.
In Africa they also found
00:14:45.71\00:14:51.15
that just about
everyone had antibodies
00:14:51.16\00:14:53.62
to Epstein-Barr virus,
so again the question was,
00:14:53.63\00:14:57.32
what triggered
the virus to progress
00:14:57.33\00:15:00.72
to Burkett's lymphoma
instead of just being either
00:15:00.73\00:15:04.36
asymptomatic infection or
one that caused mononucleosis.
00:15:04.37\00:15:10.14
Well, they got another insight
00:15:10.15\00:15:14.28
in an
observation in Africa again.
00:15:14.29\00:15:17.41
They found that immigrants
from Rwanda or Burundi
00:15:17.42\00:15:21.79
which was tumor free,
and which had no malaria.
00:15:21.80\00:15:25.44
When they came to Uganda
which had lot's of malaria,
00:15:25.45\00:15:29.56
they developed the lymphoma.
And they did it at an older age.
00:15:29.57\00:15:34.82
Remember most of
the children in Africa
00:15:34.83\00:15:36.96
were getting the lymphomas
from ages two to twelve.
00:15:36.97\00:15:40.71
But among the immigrants
to malaria infested Uganda
00:15:40.72\00:15:45.12
50 percent of them were
over the age of 15, 26 percent
00:15:45.13\00:15:49.37
were over the age of
30. What this indicated
00:15:49.38\00:15:53.52
was that somehow malaria,
getting infected with malaria
00:15:53.53\00:15:57.37
was what initiated
or allowed the virus
00:15:57.38\00:16:00.85
to progress to a
lymphoma. The mechanism allowing
00:16:00.86\00:16:05.36
the lymphoma, to appear,
appear to be immunosuppressant.
00:16:05.37\00:16:10.50
In other words the
body's immune system
00:16:10.51\00:16:13.15
was so tied up with
keeping the malaria suppressed
00:16:13.16\00:16:17.11
it had nothing
left to fight the cancer
00:16:17.12\00:16:20.48
that the virus
was trying to produce.
00:16:20.49\00:16:22.87
It had nothing
to fight the cancer
00:16:22.88\00:16:24.21
with and the virus
then progressed to cancer.
00:16:24.22\00:16:27.64
Our question is, is malaria
prevalent enough in Africa
00:16:27.65\00:16:33.03
to cause immunosuppressant
on a large scale?
00:16:33.04\00:16:36.37
In other words, can
it be the cause of these
00:16:36.38\00:16:43.63
lymphomas in Africa? And
actually yes, the, we went,
00:16:43.64\00:16:48.42
our family went on a
mission trip to Ghana
00:16:48.43\00:16:50.52
which is in the malaria belt.
And my son, while we were there,
00:16:50.53\00:16:55.17
developed
malaria and we took him
00:16:55.18\00:16:56.70
to little
Adventist hospital there.
00:16:56.71\00:16:59.20
They tested his
blood, they looked at under
00:16:59.21\00:17:00.86
the microscope and said yes,
he has a low level of malaria.
00:17:00.87\00:17:04.36
They said, if he
was a local here,
00:17:04.37\00:17:07.61
we would ignore it
because every one here
00:17:07.62\00:17:10.34
has a low level of malaria,
but they become immune to it,
00:17:10.35\00:17:14.02
and their immune system
is fighting it constantly.
00:17:14.03\00:17:16.93
But as a
foreigner this is lethal
00:17:16.94\00:17:19.98
to him unless it's
treated. So we treated it
00:17:19.99\00:17:23.40
and he got better and
of course he survived.
00:17:23.41\00:17:26.99
However, it did
illustrated the point
00:17:27.00\00:17:29.90
that in these
malaria infested places,
00:17:29.91\00:17:32.43
malaria is rampant
and it is continuing
00:17:32.44\00:17:35.08
to cause immunosuppressant
00:17:35.09\00:17:36.94
as it is a burden
on the immune system.
00:17:36.95\00:17:42.27
And with this
immunosuppressive state,
00:17:42.28\00:17:44.84
viruses like Epstein-Barr virus
can progress to cause lymphomas.
00:17:44.85\00:17:52.25
Are there other
forms of immunosuppressant
00:17:52.26\00:17:54.37
that can cause
and lead to cancer?
00:17:54.38\00:17:56.67
Yes actually there are,
00:17:56.68\00:17:57.91
HIV is the
classic viral infection
00:17:57.92\00:17:59.93
which causes
severe immunosuppressant
00:17:59.94\00:18:01.81
by destroying
certain T-lymphocytes.
00:18:01.82\00:18:04.86
Can this lead to
cancer? Yes, actually quoting
00:18:04.87\00:18:08.27
from an internal
medicine text book up to date.
00:18:08.28\00:18:12.85
It says, HIV
infected individuals
00:18:12.86\00:18:15.08
have an increased propensity
to develop malignancy.
00:18:15.09\00:18:18.28
The spectrum of neoplasm
in these patients is changing
00:18:18.29\00:18:21.05
especially in
developed portions of the world
00:18:21.06\00:18:23.02
or the vast reduce of highly
active antiretroviral therapy
00:18:23.03\00:18:27.10
has limited the
immunosuppressant associated
00:18:27.32\00:18:29.40
with the HIV for prolonged
periods in most patients.
00:18:29.41\00:18:34.26
It continues, it
says the occurrence
00:18:34.27\00:18:36.26
of an unusually
high number of cases
00:18:36.27\00:18:38.89
and an aggressive clinical
course of Kaposi's sarcoma
00:18:38.90\00:18:42.10
which is another
cancer was noted early
00:18:42.11\00:18:45.83
in the AIDS
epidemic and Kaposi's sarcoma
00:18:45.84\00:18:48.98
was included in the
AIDS defining illnesses
00:18:48.99\00:18:52.22
in early case
definitions of the,
00:18:52.23\00:18:54.56
from the centers of
diseases control and prevention.
00:18:54.57\00:18:57.47
Non-Hodgkin's lymphoma
is another type of cancer
00:18:57.48\00:19:00.48
and invades cervical
cancers were subsequently added
00:19:00.49\00:19:04.81
to the AIDS defining conditions,
00:19:04.82\00:19:08.50
and this was in 1985
and 1993 respectively.
00:19:08.51\00:19:12.94
What they are
showing is that if you have
00:19:12.95\00:19:15.34
the viral
infection and it suppresses
00:19:15.35\00:19:18.66
your immune system by
suppressing your T-cells,
00:19:18.67\00:19:21.70
you are prone to develop cancers
in that suppressed immune state.
00:19:21.71\00:19:28.45
If this is the case, if
a depressed immune system
00:19:28.46\00:19:31.79
can allow cancers to
develop from a virus,
00:19:31.80\00:19:34.44
and then we would
think that strengthening
00:19:34.45\00:19:37.34
and stimulating immune
system to fight the cancer
00:19:37.35\00:19:40.00
would be effective and
useful for cancer patients.
00:19:40.01\00:19:44.52
We'll find out that fever
is actually such a stimulation
00:19:44.53\00:19:48.49
and in fact fevers
do turn on and stimulate
00:19:48.50\00:19:52.12
the immune system and thus aid
00:19:52.13\00:19:53.95
in combating
infections and cancers.
00:19:53.96\00:19:57.49
In fact, as we know,
when you're infected,
00:19:57.50\00:20:00.38
you do get a fever many times.
00:20:00.39\00:20:03.51
And many times
when you have a cancer,
00:20:03.52\00:20:05.70
sometimes the only
symptom you have are fevers,
00:20:05.71\00:20:09.42
night sweats, chills.
This is a sign that your body
00:20:09.43\00:20:13.73
is trying to turn
on your immune system
00:20:13.74\00:20:16.80
through the mechanism of fever
to help fight these infections.
00:20:16.81\00:20:19.92
We had a patient come
at our clinic at one point
00:20:19.93\00:20:23.96
and his only
complain was fevers,
00:20:23.97\00:20:26.84
chills, night sweats.
00:20:26.85\00:20:29.33
We did some
tests cultured him up,
00:20:29.34\00:20:32.55
make sure he didn't had
any infection, he didn't.
00:20:32.56\00:20:35.22
Then we screened him
for autoimmune diseases,
00:20:35.23\00:20:39.26
mental logical
diseases, he didn't have these.
00:20:39.27\00:20:43.12
And then I said
well, we gonna need
00:20:43.13\00:20:44.61
to screen you for
cancer, and the CAT Scan
00:20:44.62\00:20:47.29
of the abdomen showed
a Renal Cell Carcinoma
00:20:47.30\00:20:49.90
above one of the,
in one of the kidneys,
00:20:49.91\00:20:54.23
he had that
treated and did well.
00:20:54.24\00:20:57.45
But the only symptom
that he had at that time
00:20:57.46\00:21:00.94
were the fevers, the
chills and the night sweats.
00:21:00.95\00:21:05.75
Do fevers indeed
turn on the immune system
00:21:05.76\00:21:09.12
and stimulate it,
so that it is effective
00:21:09.13\00:21:11.29
in fighting
infections in cancers?
00:21:11.30\00:21:14.45
Matthew Kluger who did
much of the early research
00:21:14.46\00:21:17.29
in the benefits of
fever, and actually included
00:21:17.30\00:21:22.09
in the book called Fever.
00:21:22.10\00:21:25.87
In the book he
makes the statement,
00:21:25.88\00:21:27.56
he says, you know,
today fever is precede
00:21:27.57\00:21:29.61
to something that
needs to be suppressed,
00:21:29.62\00:21:31.44
yet historically, it
was proceed as beneficial.
00:21:31.45\00:21:36.73
We find that Hypocrisies
as far back as 400 BC
00:21:36.74\00:21:41.86
said that nature
never needs any instruction.
00:21:41.87\00:21:46.21
He wrote that during
and also viral infection
00:21:46.22\00:21:48.09
that if you got a fever,
this was a favorable sign
00:21:48.10\00:21:51.60
that the infection
was going to clear.
00:21:51.61\00:21:55.70
Rufus of Ephesus
from 100 AD wrote,
00:21:55.71\00:21:58.88
I think you cannot find another
drug which heals anymore,
00:21:58.89\00:22:03.12
anymore
penetrating manner than fever.
00:22:03.13\00:22:05.55
For this reason
it's a good remedy,
00:22:05.56\00:22:07.63
for individuals
sees with convulsions
00:22:07.64\00:22:09.56
and if they were a physician
skilled enough to produce
00:22:09.57\00:22:11.76
a fever would be useless
to seek any other remedy.
00:22:11.77\00:22:16.49
Later in the 1600s,
noted English physician
00:22:16.50\00:22:21.11
Thomas
Sydenham, he wrote theory,
00:22:21.12\00:22:24.03
he said fever is nature's engine
which it brings into the field
00:22:24.04\00:22:28.34
to remove her enemy. That
was very stood observation.
00:22:28.35\00:22:33.28
Lieber Meister around
1887, he also thought fevers
00:22:33.29\00:22:37.49
of modern
magnitude or high magnitude
00:22:37.50\00:22:39.94
for short periods of
time were beneficial.
00:22:39.95\00:22:41.96
He cautioned against
fevers of long period because
00:22:41.97\00:22:45.36
these can be debilitating.
It does take energy
00:22:45.37\00:22:47.74
and effort to produce a fever
just like climbing a mountain
00:22:47.75\00:22:50.39
and it can wear a
person out. Only in high fevers
00:22:50.40\00:22:55.11
for a long periods of time
did he advocate antipyretics
00:22:55.12\00:22:58.52
or medications which
would lower the fevers
00:22:58.53\00:23:02.75
Well, today there is a
widespread trend to reduce
00:23:02.76\00:23:07.11
all fevers with antipyretics.
00:23:07.12\00:23:09.90
And Kluger makes a
comment in his book,
00:23:09.91\00:23:12.85
he says, "That one might surmise
from this widespread attempt
00:23:12.86\00:23:16.81
to reduce fevers
that convincing evidence
00:23:16.82\00:23:18.68
have been
presented which demonstrated
00:23:18.69\00:23:20.38
that fevers were
harmful. But in fact,
00:23:20.39\00:23:23.06
this is not the case,
if any thing the weight
00:23:23.07\00:23:26.12
of evidence tends to support
the opposite conclusion."
00:23:26.13\00:23:30.75
So what exactly is the evidence
that febrile temperatures
00:23:30.76\00:23:35.82
are beneficial for infections.
00:23:35.83\00:23:38.22
Well, late in the
1800s Louis Pasteur
00:23:38.23\00:23:41.79
was studying Anthrax,
and he was trying to develop
00:23:41.80\00:23:44.76
a vaccine for it.
He could easily induce
00:23:44.77\00:23:48.36
Anthrax in sheep and
cows, but he couldn't induce
00:23:48.37\00:23:53.55
Anthrax in
chickens. This concerned him
00:23:53.56\00:23:57.44
and he wondered why?
He told the colleague
00:23:57.45\00:23:59.27
of his that he couldn't
induce fevers in chickens.
00:23:59.28\00:24:02.82
The colleague challenged
him, and said, I can do it.
00:24:02.83\00:24:05.62
And but after months of trying,
00:24:05.63\00:24:08.09
his colleague finally had
to admit, he said, you know,
00:24:08.10\00:24:10.22
I can't induce
Anthrax in chickens.
00:24:10.23\00:24:12.88
You know, he'd take the
blood of an Anthrax victim
00:24:12.89\00:24:16.12
and inject in the
chickens, they just ignore it.
00:24:16.13\00:24:18.48
Then Louis Pasteur
said well, in this interim
00:24:18.49\00:24:21.55
I've found a way to
induce Anthrax in chickens.
00:24:21.56\00:24:25.52
And his colleague was stunned,
he said, how did you it?
00:24:25.53\00:24:28.89
He says, well, what we
notice was that the cows
00:24:28.90\00:24:31.86
and the sheep
that develop Anthrax
00:24:31.87\00:24:35.90
have temperatures running
around at 38 degrees Celsius.
00:24:35.91\00:24:39.37
But the chickens
have temperatures running
00:24:39.38\00:24:41.82
40 to 42 degrees
Celsius. And I thought possibly
00:24:41.83\00:24:46.27
this higher temperature is
protective for the chickens.
00:24:46.28\00:24:49.47
So he did an
experiment, took a chicken,
00:24:49.48\00:24:53.22
a normal chicken in is
normal body temperature
00:24:53.23\00:24:55.81
40 to 42 degree
Celsius, injecting with Anthrax,
00:24:55.82\00:24:58.88
chicken ignored the Anthrax.
He took another chicken wired
00:24:58.89\00:25:02.85
his feet to a
screen, put the screen
00:25:02.86\00:25:05.76
in some cool water
lowered his temperature down
00:25:05.77\00:25:07.88
to 38 degree Celsius,
injected him with Anthrax
00:25:07.89\00:25:11.26
it was dead in 24 hours.
And then took another chicken,
00:25:11.27\00:25:17.06
do the same treatment,
put his feet on wire grating,
00:25:17.07\00:25:21.01
put the wire
grating in a cool water.
00:25:21.02\00:25:23.45
Lower it's temperature
to 38 degrees Celsius,
00:25:23.46\00:25:25.70
injected him with
Anthrax and in a couple of hours
00:25:25.71\00:25:28.35
he started to become
listless, tired, he looked like
00:25:28.36\00:25:33.83
he's gonna pass out, this
were the signs of Anthrax.
00:25:33.84\00:25:36.73
At that point, they
took out of the water bath,
00:25:36.74\00:25:39.00
warmed him up, dried him
off and his temperature rose,
00:25:39.01\00:25:44.92
and he survived
the Anthrax infection.
00:25:44.93\00:25:47.67
This is the striking example
of the beneficial effects
00:25:47.68\00:25:51.16
of the higher temperatures
found in the chickens.
00:25:51.17\00:25:55.71
Then there was a human example
of the benefits of fever.
00:25:55.72\00:25:59.55
This was first described
by Hippocrates in 450- 357 BC.
00:25:59.56\00:26:06.91
He described a
mysterious diseases called
00:26:06.92\00:26:09.70
Progressive
Paralysis at that time,
00:26:09.71\00:26:11.80
it would leave
the victims paralyzed.
00:26:11.81\00:26:14.49
But he observed
that in rare cases,
00:26:14.50\00:26:17.04
a cure or long
lasting remission could occur
00:26:17.05\00:26:19.83
if the victim
acquired an infectious disease
00:26:19.84\00:26:22.25
accompanied by a high
fever. He thought that somehow
00:26:22.26\00:26:25.57
this high fever maybe
helping to resolve the illness.
00:26:25.58\00:26:30.40
But it wasn't until 1858
that Esmark and Jensen showed
00:26:30.41\00:26:34.90
that this progressive paralysis
was caused by syphilis.
00:26:34.91\00:26:38.06
They could actually
see the little spirochetes
00:26:38.07\00:26:39.84
in the blood samples of people
with this progressive paralysis.
00:26:39.85\00:26:44.32
In 1887 Wagner
Jerrick, he was psychiatrist
00:26:44.33\00:26:48.39
researching neurosyphilis,
and he noted that in China
00:26:48.40\00:26:51.51
and India both syphilis
and malaria were rampant.
00:26:51.52\00:26:56.42
But strangely enough in China
and India they are very rarely
00:26:56.43\00:27:00.06
found paralysis
from the syphilis.
00:27:00.07\00:27:03.74
And he hypothesized
that possibly the fevers
00:27:03.75\00:27:07.63
from the malaria were helping
protect him from the paralysis.
00:27:07.64\00:27:16.66
So what he did, was he
actually took patients,
00:27:16.67\00:27:20.18
injected them
with malaria in 1927
00:27:20.19\00:27:24.04
and he found that three of
them, their paralysis resolved.
00:27:24.05\00:27:27.61
He was so successful, he
treated thousands of patients
00:27:27.62\00:27:30.02
with malaria and
found that they were getting
00:27:30.03\00:27:34.85
a 30 percent cure rate.
He then won the Noble Prize
00:27:34.86\00:27:38.96
in medicine for his
work with treating syphilis
00:27:38.97\00:27:42.46
by malarial treatments
and this was established
00:27:42.47\00:27:47.84
as a very
effective cure at that time.
00:27:47.85\00:27:51.05
We're going to
continue on our work with,
00:27:51.06\00:27:55.19
looking into fevers in
immune system in our next visit.
00:27:55.20\00:27:59.20
Hope to see you there,
may God bless as you, as He,
00:27:59.21\00:28:04.02
and pray that you remain
healthy in the mean time.
00:28:04.03\00:28:07.77