The following program presents principles 00:00:01.98\00:00:02.95 designed to promote good health 00:00:02.96\00:00:03.99 and is not intended to take the place of 00:00:04.00\00:00:06.05 personalized professional care. 00:00:06.06\00:00:07.91 The opinions and ideas expressed are those 00:00:07.92\00:00:10.75 of the speaker. Viewers are encouraged 00:00:10.76\00:00:12.94 to draw their own conclusions 00:00:12.95\00:00:14.33 about the information presented. 00:00:14.34\00:00:16.16 Hello and welcome to Wonderfully Made, 00:00:37.27\00:00:38.98 are you interested in leading a lifestyle 00:00:38.99\00:00:41.99 that can help in preventing cancer? 00:00:42.00\00:00:43.71 My name is Don Morgan and I'm an exercise 00:00:45.01\00:00:48.34 physiologist and a professor in the 00:00:48.35\00:00:51.12 Department of Health and Human Performance 00:00:51.13\00:00:53.20 at Middle Tennessee State University. 00:00:53.21\00:00:55.29 This is the eight in a series of programs 00:00:56.27\00:00:59.01 describing the many health and fitness 00:00:59.02\00:01:01.09 benefits that result from adopting a 00:01:01.10\00:01:03.51 physically active lifestyle. 00:01:03.52\00:01:04.86 In today's program we're going to discuss 00:01:05.61\00:01:09.07 the role that physical activity 00:01:09.08\00:01:11.03 and exercise can play in improving 00:01:11.04\00:01:13.91 physical function and quality 00:01:13.92\00:01:16.10 of life in cancer survivors. 00:01:16.11\00:01:18.79 The term cancer actually describes over 00:01:20.54\00:01:24.19 100 diseases that can occur in just about 00:01:24.20\00:01:27.11 any body tissue or organ. Normally, 00:01:27.12\00:01:31.62 body cells grow, divide and die in a tightly 00:01:31.63\00:01:37.27 regulated fashion. With cancer however 00:01:37.28\00:01:41.58 there is an uncontrolled growth in spread of 00:01:41.59\00:01:45.00 abnormal cells that can destroy surrounding 00:01:45.01\00:01:48.01 tissues and migrate to other areas of the body. 00:01:48.02\00:01:51.65 Most cancers can be classified into 00:01:53.31\00:01:55.93 one of four categories. Carcinomas, 00:01:55.94\00:01:59.60 which develop from cells that cover glands, 00:02:00.36\00:02:02.64 internal organs and the surface of the body 00:02:02.65\00:02:05.49 account for 80 to 90 percent of all cancers. 00:02:05.50\00:02:09.39 Prostate, colon and breast cancers are 00:02:10.26\00:02:14.20 examples of carcinomas. Leukemia's are cancers 00:02:14.21\00:02:19.21 arising from cells in the blood. 00:02:19.22\00:02:21.09 Lymphomas which involve cells of the 00:02:21.50\00:02:24.83 immune system, and sarcomas which occur in 00:02:24.84\00:02:28.90 connective tissue or other types of cancer. 00:02:28.91\00:02:32.24 Based on information from the American 00:02:33.65\00:02:36.50 Cancer Society, Americans have about 00:02:36.51\00:02:40.17 a 41 percent chance of developing 00:02:40.18\00:02:42.32 some form of invasive cancer during 00:02:42.33\00:02:44.41 their lifetime. According to the Centers 00:02:44.42\00:02:48.09 for Disease Control, cancer was the second 00:02:48.10\00:02:51.59 leading cause of death in the United States 00:02:51.60\00:02:53.72 in 2003 and accounted for 23 percent 00:02:53.73\00:02:58.19 of all deaths. However in the latest report 00:02:58.20\00:03:03.63 from the American Cancer Society more 00:03:03.64\00:03:06.70 American's under the age of 85 actually 00:03:06.71\00:03:09.36 died of cancer rather then heart diseases 00:03:09.37\00:03:12.21 which still remains the leading cause of death 00:03:12.22\00:03:15.13 in the U.S. Interestingly, while the 00:03:15.14\00:03:19.87 very oldest American's continue to die of 00:03:19.88\00:03:22.41 heart diseases more than they do of cancer 00:03:22.42\00:03:24.90 this trend is expected to reverse itself 00:03:26.30\00:03:28.50 by the year 2018. With age the probability of 00:03:28.51\00:03:34.63 developing most cancers increases markedly 00:03:34.64\00:03:37.49 which makes cancer a disease that 00:03:38.30\00:03:40.95 primarily affects older adults. 00:03:40.96\00:03:42.93 However some cancers like Hodgkin's disease, 00:03:44.49\00:03:48.28 non-Hodgkin's lymphoma, leukemia 00:03:48.29\00:03:51.55 and testicular cancer affect mostly 00:03:51.56\00:03:55.14 younger persons. Currently the five year 00:03:55.15\00:04:00.01 relative survival rate for cancer is about 00:04:00.02\00:04:02.51 60 percent although this figure varies 00:04:02.52\00:04:06.26 depending on the type of cancer detected 00:04:06.27\00:04:09.38 and the extent of the diseases 00:04:09.39\00:04:12.12 when it's diagnosed. Given the increase in 00:04:12.13\00:04:16.35 cancer incidents and the increase in 00:04:16.36\00:04:19.38 survival rates fitness professionals can expect 00:04:19.39\00:04:22.96 to serve a growing numbers of 00:04:22.97\00:04:24.38 cancer survivors in the future. 00:04:24.39\00:04:26.70 The following graphic displays risk factors 00:04:28.21\00:04:31.36 for cancer, as shown in this figure many causes 00:04:31.37\00:04:35.78 of cancer are linked to the lifestyle behaviors. 00:04:35.79\00:04:38.16 It is a particular interest to know 00:04:39.65\00:04:41.84 that the combined influence of diet 00:04:41.85\00:04:44.08 and physical inactivity is the single largest 00:04:44.09\00:04:47.15 cancer risk factor. When added in with 00:04:47.16\00:04:50.84 tobacco use as many as 65 percent 00:04:50.85\00:04:54.46 of all cancers may be preventable 00:04:54.47\00:04:57.19 by not smoking, eating a healthy diet, 00:04:57.20\00:05:00.62 performing regular physical activity 00:05:01.44\00:05:03.49 and maintaining a healthy weight. 00:05:04.30\00:05:06.08 In studying the potential relationship 00:05:08.82\00:05:10.90 between physical inactivity in cancer 00:05:10.91\00:05:13.46 it's important to recognize that the link 00:05:13.47\00:05:16.09 between these two factors is not new. 00:05:16.10\00:05:18.30 In a text written over 300 years ago 00:05:20.02\00:05:22.88 it was suggested that physical activity 00:05:22.89\00:05:25.81 might play a role in the expression 00:05:25.82\00:05:28.06 of human cancer. In 1922 Australian 00:05:28.07\00:05:33.22 researchers noted that primitive tribes 00:05:33.23\00:05:35.79 who worked continuously for food displayed 00:05:35.80\00:05:39.46 lower rates of cancer compared to people 00:05:39.47\00:05:41.85 living in more civilized societies. 00:05:41.86\00:05:44.44 In the same year it was also observed that 00:05:45.35\00:05:48.93 most cancer patients led relatively 00:05:48.94\00:05:51.03 inactive lives and that men who worked hard 00:05:51.04\00:05:54.50 were less cancer prone compared to those 00:05:54.51\00:05:57.76 who tended to sit while performing daily work 00:05:57.77\00:06:00.85 activities. Later in the 1970's other scientists 00:06:00.86\00:06:06.77 observed that a lower cancer risk seem to be 00:06:06.78\00:06:09.70 present in former athletes, people 00:06:09.71\00:06:12.93 who were employed in active occupations 00:06:12.94\00:06:15.49 and those who exercised during 00:06:16.40\00:06:18.37 their leisure time. The following graphic 00:06:18.38\00:06:22.17 depicts the relationship between overall 00:06:22.18\00:06:24.27 cancer death rates and fitness status 00:06:24.28\00:06:27.07 in a large cohort of men and woman who have 00:06:27.08\00:06:29.95 studied at the Institute For Aerobics Research 00:06:29.96\00:06:32.63 in Dallas, Texas as shown in this figure 00:06:32.64\00:06:37.00 men and women who displayed good 00:06:37.01\00:06:39.61 fitness levels exhibited much lower age 00:06:39.62\00:06:42.85 adjusted cancer death rates then those with 00:06:42.86\00:06:46.08 poor fitness levels. However what is perhaps 00:06:46.09\00:06:50.57 most striking about these finding is that 00:06:50.58\00:06:53.65 those individuals who displayed just 00:06:53.66\00:06:55.73 average levels of fitness demonstrated 00:06:55.74\00:06:58.93 marked reductions in overall cancer death 00:06:58.94\00:07:01.47 rates compared with those persons with 00:07:01.48\00:07:04.17 poor fitness levels. Similar to tracking data 00:07:04.18\00:07:08.84 for cardiovascular disease and diabetes 00:07:08.85\00:07:11.34 these results emphasize the importance of 00:07:12.35\00:07:14.72 just getting yourself in the average fitness 00:07:14.73\00:07:17.62 category by accumulating at least 30 minutes 00:07:17.63\00:07:21.20 of moderate intensity physical activity 00:07:21.21\00:07:23.53 on a regular basis. What are some of the 00:07:24.16\00:07:29.23 biological mechanisms that may help explain 00:07:29.24\00:07:32.69 the relationship between physical activity 00:07:32.70\00:07:35.13 and cancer? One possibility is that 00:07:35.14\00:07:39.81 physical activity may provide a lifestyle 00:07:39.82\00:07:42.58 protective effect by enhancing the function 00:07:42.59\00:07:45.85 of the immune system, this idea has been 00:07:45.86\00:07:49.66 tested by injecting laboratory animals 00:07:49.67\00:07:52.63 with certain types of cancer producing 00:07:52.64\00:07:54.47 chemicals assigning them to exercising 00:07:54.48\00:07:57.80 or non-exercising groups and then measuring 00:07:57.81\00:08:01.00 cancer growth. Results from these studies 00:08:01.01\00:08:04.91 have shown that exercise appears to retire 00:08:04.92\00:08:08.21 the growth of cancer at a number of sites, 00:08:08.22\00:08:11.03 in humans moderate physical activity 00:08:11.04\00:08:15.93 like brisk walking has also been shown to 00:08:15.94\00:08:20.16 enhance the function of certain cells 00:08:20.17\00:08:22.23 in the immune system like natural killer cells 00:08:22.24\00:08:25.62 which serve as the body's first line of 00:08:26.49\00:08:29.18 defense against the development 00:08:29.19\00:08:31.25 and spread of cancer. However at more 00:08:31.26\00:08:36.00 intense levels of exercise some short term 00:08:36.01\00:08:39.48 suppression of the immune system 00:08:39.49\00:08:41.17 seems to be present, viewed collectively 00:08:41.18\00:08:45.26 these findings provide further support for 00:08:45.96\00:08:48.72 engaging in a daily routine of moderate 00:08:48.73\00:08:51.57 physical activity, in addition to it's ability 00:08:51.58\00:08:55.87 to strengthen the immune system, 00:08:55.88\00:08:57.59 physical activity may further reduce 00:08:58.23\00:09:00.53 overall cancer risk by improving circulation, 00:09:00.54\00:09:03.79 ventilation, energy balance 00:09:03.80\00:09:07.63 and the ability to repair DNA. 00:09:07.64\00:09:10.29 In general evidence suggests that 00:09:12.20\00:09:15.98 physical activity may significant reduce 00:09:15.99\00:09:18.11 the chance of developing some site specific 00:09:18.12\00:09:21.12 cancers, the strongest data come from 00:09:21.13\00:09:25.83 research indicating that physical activity 00:09:25.84\00:09:28.38 may lower the risk of colon 00:09:28.39\00:09:30.82 and breast cancer by as much as 00:09:30.83\00:09:33.25 30 to 50 percent. Physical activity may 00:09:33.26\00:09:37.94 also exert a protective effect against 00:09:37.95\00:09:40.72 endometrial cancer, prostate cancer 00:09:40.73\00:09:43.82 and lung cancer. While a few researchers have 00:09:43.83\00:09:48.85 attempted to document the influence 00:09:48.86\00:09:50.81 of physical activity on ovarian, pancreatic 00:09:50.82\00:09:54.25 and stomach cancers no clear findings 00:09:54.26\00:09:57.83 have emerged. Let's take a look at the 00:09:57.84\00:10:03.65 association between physical activity 00:10:03.66\00:10:05.80 and certain types of sites specific cancers, 00:10:06.62\00:10:09.22 as mentioned earlier the evidence linking 00:10:10.45\00:10:13.91 physical activity and a reduced risk of 00:10:13.92\00:10:16.92 colon cancer appears quite convincing. 00:10:16.93\00:10:19.51 Out of 45 published studies 38 or 84 percent 00:10:20.42\00:10:26.94 have reported an average decline of 00:10:26.95\00:10:30.04 50 percent in colon cancer risk amongst 00:10:30.05\00:10:33.86 more physically active people in fact 00:10:33.87\00:10:37.88 it's been estimated that if the entire 00:10:37.89\00:10:40.79 adult population in the United States 00:10:40.80\00:10:43.11 increase it's physical activity level by just 00:10:43.12\00:10:46.34 three hours of walking per week which 00:10:46.35\00:10:49.78 translates into a daily walking time of 00:10:49.79\00:10:51.89 about 25 minutes per day there would be 00:10:51.90\00:10:55.00 17 percent fewer cases of colon cancer. 00:10:55.01\00:10:58.25 This trend is supported by result of a study 00:10:59.69\00:11:03.44 involving nearly 48,000 men aged 40 to75, 00:11:03.45\00:11:08.77 in this report the risk of colon cancer was 00:11:10.19\00:11:13.44 decreased by nearly 50 percent in the most 00:11:13.45\00:11:16.74 physically active men when compared 00:11:16.75\00:11:19.55 to their sedentary peers. Specifically 00:11:19.56\00:11:23.29 the greatest protection from colon cancer 00:11:23.30\00:11:26.07 was observed in men who were active 00:11:26.08\00:11:28.22 one to two hours per day conversely men 00:11:28.23\00:11:33.61 who were physically inactive and obese 00:11:33.62\00:11:36.31 displayed a colon cancer risk nearly five times 00:11:37.23\00:11:40.38 higher then that of their active 00:11:40.39\00:11:43.08 and more lean counterparts. 00:11:43.09\00:11:44.93 In a similar study of 89,000 women 00:11:46.41\00:11:49.64 it was found that colon cancer risk dropped by 00:11:50.35\00:11:52.91 nearly 50 percent in women who were 00:11:52.92\00:11:56.08 the most physically active. 00:11:56.09\00:11:57.72 Now what it counts for the relationship between 00:11:59.41\00:12:02.36 physical activity and a lowered risk of 00:12:02.37\00:12:05.46 colon cancer? It's known that exercise 00:12:05.47\00:12:10.10 and physical activity stimulate a process 00:12:10.11\00:12:12.52 called peristalsis or muscle movement 00:12:12.53\00:12:16.24 within the large intestine, 00:12:16.25\00:12:17.82 with enhanced peristalsis the time 00:12:18.71\00:12:22.25 that cancer causing chemical in fecal matter 00:12:22.26\00:12:24.86 remain in contact with cancer, 00:12:24.87\00:12:27.72 with colon cells is decreased thus 00:12:27.73\00:12:31.88 diminishing the exposure of the intestinal wall 00:12:31.89\00:12:34.44 to carcinogens. It is also thought that 00:12:34.45\00:12:38.24 reducing the period of contact between 00:12:38.25\00:12:40.88 carcinogens and colon cells may reduce 00:12:40.89\00:12:43.94 the growth and proliferation of 00:12:43.95\00:12:45.62 these cells. In one study looking 00:12:45.63\00:12:49.11 at the effect of modern exercise on the time 00:12:49.12\00:12:51.77 required for food residue to pass 00:12:51.78\00:12:54.67 completely through the body it was observed 00:12:54.68\00:12:57.79 that running and cycling produced much faster 00:12:57.80\00:13:00.74 transit times compared to a resting condition. 00:13:00.75\00:13:04.13 So in this sense exercise produces 00:13:05.15\00:13:09.00 the same effect on the colon as does 00:13:09.01\00:13:11.89 the ingestion of the dietary fiber, 00:13:11.90\00:13:13.89 it was also been suggested that 00:13:15.17\00:13:17.53 physically activity may lead to a lower 00:13:17.54\00:13:19.53 cancer risk by reducing obesity levels. 00:13:19.54\00:13:22.61 Support for this assertion can be found 00:13:23.46\00:13:26.71 in animal study showing that cancer risk is 00:13:26.72\00:13:29.10 lowered when energy intake is slightly 00:13:29.11\00:13:32.27 reduced below body requirements. 00:13:32.28\00:13:34.91 Both physical inactivity and obesity can raise 00:13:36.19\00:13:40.83 levels of insulin or hormone that increases 00:13:40.84\00:13:44.43 cancer risk by elevating the growth 00:13:44.44\00:13:46.95 rate of cells lining the colon. 00:13:46.96\00:13:48.94 Of course it is also possible that people 00:13:49.97\00:13:53.31 who are physically active eat more 00:13:53.32\00:13:55.94 dietary fiber which would increase 00:13:55.95\00:13:58.96 the protection against colon cancer. 00:13:58.97\00:14:00.89 However in studies where dietary fiber intake 00:14:02.31\00:14:05.91 has been controlled physically activity 00:14:05.92\00:14:08.96 is still shown to independently decrease 00:14:08.97\00:14:11.60 the risk of colon cancer. Is there a link 00:14:11.61\00:14:16.32 between physical activity and 00:14:16.33\00:14:18.04 breast cancer, out of 41 published studies 00:14:18.05\00:14:22.59 25 or 63 percent demonstrated their 00:14:23.39\00:14:27.50 occupational and leisure time physical activity 00:14:27.51\00:14:30.18 was associated with about a 30 percent 00:14:30.19\00:14:32.95 reduction in breast cancer risk. 00:14:32.96\00:14:34.71 In one study of premenopausal females, 00:14:36.12\00:14:38.69 the risk of breast cancer was reduced by 00:14:38.70\00:14:41.56 almost 60 percent in those women 00:14:41.57\00:14:44.73 who exercise in average of more then 00:14:44.74\00:14:46.57 3.7 hours per week or just more than 00:14:46.58\00:14:49.85 30 minutes per day since the start of menses, 00:14:49.86\00:14:53.01 these results highlight the importance of 00:14:54.01\00:14:56.60 leading a modernly active lifestyle 00:14:56.61\00:14:58.75 beginning early in life. In another report 00:14:58.76\00:15:03.46 leisure time physical activity in 00:15:03.47\00:15:06.17 breast cancer risk were documented 00:15:06.18\00:15:08.52 in over 25,000 women, data from this 00:15:08.53\00:15:12.70 investigation reveal that as the level of 00:15:12.71\00:15:15.24 leisure time physical activity increased from 00:15:15.25\00:15:18.68 sedentary to regular exercise, 00:15:18.69\00:15:20.81 the risk of breast cancer decreased by 00:15:21.52\00:15:23.80 37 percent. Moreover the lowest breast cancer 00:15:23.81\00:15:29.45 risk was found among women who were lean 00:15:29.46\00:15:32.12 and regularly exercised. What are 00:15:32.13\00:15:36.12 some of the potential mechanisms underlying 00:15:36.13\00:15:38.29 the relationship between greater levels of 00:15:38.30\00:15:40.78 physical activity and reductions in 00:15:40.79\00:15:42.89 breast cancer risk. Women who have 00:15:42.90\00:15:46.38 exercised rigorously from childhood 00:15:46.39\00:15:48.70 tend to have a later onset of monarchy, 00:15:48.71\00:15:51.88 some missed menstrual cycles and greater 00:15:51.89\00:15:55.35 leanness all of which lower exposure 00:15:55.36\00:15:58.64 of the breast tissue to estrogen. 00:15:58.65\00:16:00.71 Because estrogen promotes the 00:16:01.75\00:16:03.60 proliferation and the vision of the 00:16:03.61\00:16:05.20 breast cells there is a greater chance for 00:16:05.21\00:16:08.22 genetic mutations to take hold that can 00:16:08.23\00:16:10.88 result in the development of cancer. 00:16:10.89\00:16:12.83 Estrogen metabolism also generates 00:16:14.16\00:16:16.77 free radicals which can produce unstable DNA, 00:16:16.78\00:16:20.56 genetic mutations and a greater cancer risk, 00:16:20.57\00:16:24.66 in addition estrogen can stimulate 00:16:25.37\00:16:28.35 the production of receptors for other 00:16:28.36\00:16:30.57 hormones like progesterone that can 00:16:30.58\00:16:33.74 cause breast cancer cells to divide. 00:16:33.75\00:16:36.34 Related to this discussion is the fact 00:16:37.71\00:16:40.14 that obesity and especially abdominal 00:16:40.15\00:16:43.12 obesity can heighten the risk of breast cancer 00:16:43.13\00:16:46.77 by increasing estrogen levels in the body, 00:16:46.78\00:16:49.46 obesity also increases insulin which in turn 00:16:50.31\00:16:54.93 can spur the growth of breast cancer cells. 00:16:54.94\00:16:58.02 Taken together the role that exercise 00:16:59.54\00:17:02.99 may play in altering exposure to sex hormones 00:17:03.00\00:17:05.98 reducing obesity and decreasing levels of 00:17:05.99\00:17:09.26 insulin suggests that the protection against 00:17:09.27\00:17:12.55 breast cancer through physical activity is 00:17:12.56\00:17:15.76 biologically possible. Researchers have also 00:17:15.77\00:17:20.70 investigated the association between 00:17:20.71\00:17:22.72 physical activity and endometrial cancer 00:17:22.73\00:17:25.59 in light of the effects of physical activity 00:17:26.39\00:17:28.68 on the production, metabolism and excretion 00:17:28.69\00:17:32.04 of sex hormones like estrogen 00:17:32.05\00:17:34.17 and progesterone. Although the number of 00:17:34.18\00:17:37.93 published studies on this cancer are 00:17:37.94\00:17:40.16 small a relationship between 00:17:40.17\00:17:43.39 physical activity and endometrial cancer risk 00:17:43.40\00:17:46.78 has been observed. In these reports 00:17:46.79\00:17:50.46 a significantly reduced risk of 00:17:50.47\00:17:53.14 endometrial cancer was observed as 00:17:53.15\00:17:56.27 activity levels increased, 00:17:56.28\00:17:58.20 the protective effect of physical activity on 00:17:59.95\00:18:03.62 prostate cancer, the most frequently 00:18:03.63\00:18:06.49 diagnosed cancer in men is less apparent 00:18:06.50\00:18:10.03 when compared to available evidence 00:18:10.04\00:18:12.24 for cancers of the colon and breast. 00:18:12.25\00:18:14.10 Of 28 published studies 14 or 50 percent 00:18:14.78\00:18:20.09 show that occupational and leisure time 00:18:20.81\00:18:23.74 physical activity significantly decreased 00:18:23.75\00:18:26.40 cancer risk in the prostate by 00:18:26.41\00:18:29.12 10 to 70 percent. In one study involving 00:18:29.13\00:18:33.09 more than 13,000 men those exhibiting 00:18:33.10\00:18:36.85 the highest levels of aerobic fitness 00:18:36.86\00:18:38.64 displayed a 74 percent lower risk of 00:18:38.65\00:18:42.56 prostate cancer compared to men 00:18:42.57\00:18:45.12 who were least fit. The fact that the risk 00:18:45.13\00:18:48.72 for prostate cancer death has been tied to 00:18:48.73\00:18:51.19 higher body mass index values also suggest 00:18:51.20\00:18:55.89 that overweightness and obesity may be 00:18:55.90\00:18:58.96 operative factors in promoting 00:18:58.97\00:19:00.73 prostate cancer. What might explain 00:19:00.74\00:19:04.87 the association between physical activity 00:19:04.88\00:19:07.18 and a lowered risk of prostate cancer in men. 00:19:07.19\00:19:10.31 It has been hypothesized that higher levels of 00:19:11.39\00:19:14.76 testosterone may fuel the growth of 00:19:14.77\00:19:17.33 prostate cancer cells. It is also known 00:19:17.34\00:19:21.03 that athletes have lower levels of circulating 00:19:21.04\00:19:23.23 testosterone compared to non-athletes, 00:19:23.24\00:19:26.05 hence highly active men may end up 00:19:26.83\00:19:30.61 exposing their prostate glands to less 00:19:30.62\00:19:32.98 testosterone there by reducing their risk for 00:19:32.99\00:19:36.87 prostate cancer. Furthermore by 00:19:36.88\00:19:41.00 encouraging a more lean body composition 00:19:41.01\00:19:43.63 physical activity may lower the levels of 00:19:44.33\00:19:47.05 proteins and hormones that could promote 00:19:47.06\00:19:49.78 prostate tumor growth in obese men. 00:19:49.79\00:19:52.45 Lung cancer is the second most common 00:19:54.81\00:19:57.05 cancer among men and women 00:19:57.06\00:19:58.64 in the United States, like prostate cancer 00:19:58.65\00:20:02.41 the potential protective effect of 00:20:02.42\00:20:04.74 physical activity in reducing the risk of 00:20:04.75\00:20:07.44 lung cancer is not as strong as that seen for 00:20:07.45\00:20:10.43 colon and breast cancers. None the less 00:20:10.44\00:20:13.78 it has been speculated that increased 00:20:13.79\00:20:16.61 ventilation and better blood flow to the lungs 00:20:16.62\00:20:19.95 may act to reduce the concentration of 00:20:19.96\00:20:22.64 carcinogenic agents in the breathing passages 00:20:22.65\00:20:25.21 and the length of time that these agents 00:20:25.22\00:20:28.27 are in contact with the lung airways. 00:20:28.28\00:20:30.69 Limited data have shown that for lung cancer 00:20:32.07\00:20:34.79 physical activity can exhort a protective 00:20:34.80\00:20:37.55 effect of between 20 percent 00:20:37.56\00:20:39.82 and 60 percent. In these studies 00:20:39.83\00:20:42.90 it was observed that participation 00:20:42.91\00:20:45.29 in modern intensity physical activity 00:20:45.30\00:20:47.58 reduced cancer risk after adjusting 00:20:47.59\00:20:50.93 for the impact of smoking and other 00:20:50.94\00:20:53.40 potential risk factors. In summary 00:20:53.41\00:20:57.01 physical activity appears to exhort a 00:20:57.89\00:20:59.96 protective effect on certain site 00:20:59.97\00:21:02.75 specific cancers. While more research 00:21:02.76\00:21:06.09 on this topic is certainly warranted 00:21:06.10\00:21:08.06 it appears that the performance of moderate 00:21:08.79\00:21:11.41 intensity physical activity is more 00:21:11.42\00:21:14.10 beneficial then light activities in reducing 00:21:14.11\00:21:17.52 cancer risks. There are some general 00:21:17.53\00:21:21.26 guidelines that are available to help 00:21:21.27\00:21:23.40 prescribe exercise and physical activity for 00:21:23.41\00:21:26.50 otherwise healthy cancer survivors, 00:21:26.51\00:21:28.60 while the goals for cancer survivors 00:21:29.35\00:21:31.95 will vary across individuals reasonable 00:21:31.96\00:21:35.62 expectations might include being 00:21:35.63\00:21:37.90 able to exercise on a regular basis, 00:21:37.91\00:21:40.31 maintaining or improving everyday function, 00:21:40.32\00:21:43.55 optimizing general health, managing 00:21:44.25\00:21:47.20 specific symptoms and side effects of 00:21:47.21\00:21:49.53 medical treatment and preventing diseases 00:21:49.54\00:21:52.45 like osteoporosis, the cancer survivors are 00:21:52.46\00:21:56.16 at a higher risk for it. With respect to 00:21:56.17\00:21:59.81 activity mode walking and cycling are often 00:21:59.82\00:22:02.85 recommended because they are safe activities 00:22:02.86\00:22:06.22 that can be done at a controlled 00:22:06.23\00:22:07.87 moderate intensity and a low impact 00:22:07.88\00:22:10.79 in nature. For certain individuals activity 00:22:10.80\00:22:15.50 may need to be modified based on patient 00:22:15.51\00:22:18.46 preference as well as the short 00:22:18.47\00:22:21.11 and long term treatment effects of surgery, 00:22:21.12\00:22:24.09 chemotherapy, and radiation therapy. 00:22:24.10\00:22:27.40 While the frequency of exercise should be 00:22:28.34\00:22:30.52 at least three to five times per week. 00:22:30.53\00:22:32.92 Exercise done at lighter intensities 00:22:33.66\00:22:36.11 or for shorter time periods may be optimal 00:22:36.12\00:22:39.23 for deconditioned cancer patients. 00:22:39.24\00:22:41.79 While it is recommend that exercise 00:22:42.62\00:22:45.39 duration be at least 20 to 30 minutes 00:22:45.40\00:22:47.90 accumulating shorter physical activity 00:22:48.58\00:22:51.08 bouts with intervening rest periods is a 00:22:51.09\00:22:54.87 reasonable alternative for patients 00:22:54.88\00:22:56.83 who are less fit, or who are experiencing 00:22:56.84\00:22:59.40 severe side effects from treatment. 00:22:59.41\00:23:01.79 With time the volume of exercise performed 00:23:02.69\00:23:06.49 can be raised, first by increasing frequency 00:23:06.50\00:23:09.79 and duration and later by raising 00:23:09.80\00:23:13.01 intensity level. The progression of the 00:23:13.02\00:23:16.30 exercise program should be slowing gradual 00:23:16.31\00:23:19.13 for deconditioned persons and for 00:23:19.14\00:23:22.23 individuals for whom treatment side effects 00:23:22.24\00:23:24.98 might be especially problematic. 00:23:24.99\00:23:27.66 It should also be remembered that 00:23:28.97\00:23:30.93 fluctuations in the ability to perform 00:23:30.94\00:23:33.07 physical activity ought to be expected. 00:23:33.08\00:23:35.70 In addition to the physiological benefits 00:23:36.37\00:23:38.88 that are gained from adopting an active 00:23:38.89\00:23:40.68 lifestyle, the improvement in 00:23:40.69\00:23:42.79 psychological health that results from being 00:23:42.80\00:23:44.94 physically active is a prime significance 00:23:44.95\00:23:47.75 for the cancer survivor. When creating 00:23:47.76\00:23:50.75 a physical activity program for a person 00:23:50.76\00:23:53.07 with cancer it is important to recognize 00:23:53.08\00:23:55.91 that medical treatments and disease related 00:23:55.92\00:23:58.69 declines in physical functions probably 00:23:58.70\00:24:01.41 account for at least some of the 00:24:01.42\00:24:03.23 psychological and emotional burdens 00:24:03.24\00:24:05.84 of the cancer experience, these can 00:24:05.85\00:24:08.55 include depression, anxiety, body image 00:24:08.56\00:24:11.64 concerns, decreased self esteem 00:24:11.65\00:24:14.20 and a loss of control. A successful physical 00:24:14.21\00:24:18.33 activity program is one that is enjoyable 00:24:18.34\00:24:20.86 and builds self-confidence. 00:24:20.87\00:24:22.83 Other factors that may positively impact 00:24:23.69\00:24:25.96 activity programming for the cancer survivor 00:24:25.97\00:24:28.34 include the development of new skills 00:24:28.35\00:24:30.95 and the facilitation of social interaction. 00:24:30.96\00:24:34.11 In an earlier program we discussed barriers to 00:24:35.34\00:24:38.98 exercise and identify it's specific strategies 00:24:38.99\00:24:42.11 to overcome them, for the cancer survivor 00:24:42.12\00:24:45.80 incentives to participate in exercise 00:24:45.81\00:24:48.83 and barriers preventing exercise also exist, 00:24:48.84\00:24:52.20 not surprisingly many of the incentives 00:24:53.00\00:24:55.90 for the cancer survivor such as maintaining 00:24:55.91\00:24:58.48 a normal lifestyle, feeling better, 00:24:58.49\00:25:01.05 improving psychological well being 00:25:01.06\00:25:03.89 and securing general health benefits are 00:25:03.90\00:25:07.10 similar to those which might be appropriate 00:25:07.11\00:25:09.09 for the general population. 00:25:09.10\00:25:10.53 However other incentives like recovering 00:25:10.54\00:25:14.17 from surgery and treatment, 00:25:14.18\00:25:15.50 gaining control over cancer and once life 00:25:15.51\00:25:18.99 and coping with the stress of cancer 00:25:19.00\00:25:21.35 are unique to the cancer survivor, 00:25:21.36\00:25:23.60 likewise barriers to exercise such as 00:25:24.30\00:25:27.50 bad weather, fatigue and lack of time 00:25:27.51\00:25:30.59 are common to many individuals, 00:25:30.60\00:25:32.83 others like nausea and diarrhea 00:25:32.84\00:25:36.13 would again be specific to the patient 00:25:36.14\00:25:39.03 with cancer. It is critical that the 00:25:39.04\00:25:42.02 medical support team recognize the cancer 00:25:42.03\00:25:44.70 survivors will have special incentives 00:25:44.71\00:25:47.19 and barriers to physical activity that must be 00:25:47.20\00:25:50.38 addressed when creating a personalized 00:25:50.39\00:25:52.99 physical activity program. I like to end 00:25:53.00\00:25:57.12 today by recounting a personal story 00:25:57.13\00:25:59.66 of a woman from Australia who is a 00:25:59.67\00:26:02.08 long term survival of breast cancer. 00:26:02.09\00:26:04.42 It has been more than three decades 00:26:05.15\00:26:07.06 since Bettina Woodburn was diagnosed with 00:26:07.07\00:26:10.06 breast cancer, after learning about 00:26:10.07\00:26:12.95 the warning signs of breast cancer 00:26:12.96\00:26:14.88 Bettina checked her breasts and found a lump 00:26:14.89\00:26:17.83 soon there after she underwent both 00:26:18.63\00:26:20.98 lumpectomy and a mastectomy. 00:26:20.99\00:26:23.27 Following these surgeries Bettina 00:26:24.00\00:26:26.34 returned to being a wife and a mother of 00:26:26.35\00:26:28.71 four children but she was in her own words 00:26:28.72\00:26:32.24 shattered and in shock from the entire 00:26:32.25\00:26:35.68 experience. Eventually Bettina became 00:26:35.69\00:26:39.68 more positive about her cancer recovery 00:26:39.69\00:26:41.86 and spent the time between the ages of 00:26:41.87\00:26:44.45 50 and 60 becoming very physically fit in order 00:26:44.46\00:26:48.80 to fight the further spread of the diseases. 00:26:48.81\00:26:50.88 She also became mentally fit earning 00:26:50.89\00:26:54.22 three academic degrees, in addition to 00:26:54.23\00:26:57.60 kayaking and bicycling to strengthen 00:26:57.61\00:26:59.81 and improve the efficiency of her arms 00:26:59.82\00:27:01.57 and legs she joined what is known as 00:27:01.58\00:27:04.31 Veteran Athletics when she was 60 00:27:04.32\00:27:06.80 and competed in running, throwing 00:27:06.81\00:27:08.90 and jumping events. At one point Bettina 00:27:08.91\00:27:12.83 held 15 Australian records in the Veteran 00:27:12.84\00:27:15.57 and Masters Games and she was the medalist 00:27:15.58\00:27:18.51 in the world games in Rome and Melbourne. 00:27:18.52\00:27:20.82 She has also kayaked to raise money for 00:27:20.83\00:27:23.49 breast cancer research and now over 80 00:27:23.50\00:27:26.39 she still rides a road racing bike. 00:27:26.40\00:27:29.02 Bettina's story is inspiring not only 00:27:29.03\00:27:33.10 because she successfully overcame 00:27:33.11\00:27:34.99 breast cancer but also because 00:27:35.00\00:27:37.57 she fought the demons of self doubt 00:27:37.58\00:27:39.71 and negativity and adopted a 00:27:39.72\00:27:42.47 positive attitude about her recovery. 00:27:42.48\00:27:44.59 For Bettina, physical activity was an 00:27:45.17\00:27:47.77 important part of her recovery plan 00:27:47.78\00:27:49.56 and it is something that has become 00:27:49.57\00:27:51.31 part of her normal lifestyle. 00:27:51.32\00:27:52.79 When asked about the most important 00:27:52.80\00:27:55.46 health message she could give to other women 00:27:55.47\00:27:57.49 who have cancer her response was this, 00:27:57.50\00:28:00.08 stop grieving and realize that you can 00:28:00.09\00:28:02.93 fight cancer. Watch your health 00:28:02.94\00:28:05.16 and aim for fitness and fun, 00:28:05.17\00:28:06.68 this is a message that can apply to all of us. 00:28:06.69\00:28:09.52 So until next time keep moving 00:28:09.53\00:28:12.46 step by step towards better fitness. 00:28:12.47\00:28:15.04