The following program presents
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principles designed
to promote good health
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and is not
intended to take the place
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of personalized
professional care.
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The opinions and
the ideas expressed
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are those of the speaker.
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Viewers are encouraged to draw
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their own conclusions
about the information presented.
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Hello, and welcome to
Health for A Lifetime.
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I'm your host Don Mackintosh.
We're glad you're with us,
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and we're glad Dr.
Neil Nedley is with us.
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Welcome Dr. Nedley. Thank
you, it's good to be here.
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And you're a
physician in internal medicine
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which means you
deal with organs systems,
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the complex
patient, heart problems,
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all kinds of
problems that are inside.
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Adult disease of
the internal organs.
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Okay, adult diseases
of the internal organs.
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So, today we're
gonna kind of just update
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people on Cutting
The Edge Research.
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We're gonna look
at different things.
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We'll look at a
bunch of different things.
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We're gonna be looking
at diabetes and depression.
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We're gonna be looking
at, you know, waistlines
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and how they had
increased during college.
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We're gonna be
looking at Red Yeast
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and all kinds of
these interesting things.
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And why don't we
just dive right into it?
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Our first study comes from
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the Journal of the
American Medical Association
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published in June 18 of 2008,
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showing a link between
Diabetes and depression.
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It turns out that people being
treated for Type II Diabetes
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are at increased
risk for depression.
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And also those who have
depression are moderately
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increased in their risk of
developing Type II Diabetes.
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In fact, they found that people
who had symptoms of Depression
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were about 30% more
likely to develop Diabetes
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during the study then
people without Depression.
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And they think
this link is not only
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just due to lifestyle factors
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or some of those
lifestyle factors
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that cause
Diabetes for instance, Don,
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also end up causing Depression.
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But also the fact
that these two diseases
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are interrelated
through deeper mechanisms.
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And what are some of
those deeper mechanisms?
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Well, the deeper mechanisms
would be insulin resistance.
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People with Type II Diabetes
developed insulin resistance
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and that means that
the insulin can't get
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out of the receptor, to
get the sugar into the cell,
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okay, and if the sugar
doesn't get into the cell
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it doesn't get energy
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and obviously that can be
associated with fatigue, apathy,
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and also the
devolvement of Type II Diabetes.
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And so the interesting thing
about this is the same treatment
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that can help Diabetes
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also can help
Depression and vice versa.
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So you know, for
years we've known
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it's good for
diabetics to exercise
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and it's good for them
to eat plant-based foods,
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but it turns out
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that is the best
program for Depressions as well.
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So do you think underlying
this is the Obesity crisis
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that we face in
many Western Countries?
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Yes, that's part of it.
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We're seeing
increasing waistlines
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and of course that can
cause insulin resistance
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and can also lead
to Diabetes we know.
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And now we know it can
also lead to Depression.
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I looked at the study
once that said you know,
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one out of every three patients
that's Obese has Depression
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and so it was
kind of that link too.
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There is that
link and that's why,
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you know, we of course of author
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the Depression recovery program,
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but that's why we
talked about if you're obese
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loosing weight
down to your idea way.
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It'll actually help your energy,
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it'll help your
insulin resistance
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and what happens
that you'll also,
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you know, we
didn't talked about this
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to get the
neurotransmitters into the brain
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or I should say the substrate
to make the neurotransmitters,
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for instance the
substrate to make Serotonin
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is called Tryptophan.
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Tryptophan, we
have to get in foods.
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Tryptophan will not
cross into the brain,
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unless the insulin is working.
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In other words, the
insulin binds another receptor
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and that brings
tryptophan across
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the blood brain
barrier to make Serotonin.
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So in another words, insulin
doesn't just get sugar in,
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it gets these other
building blocks into the brain
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that didn't could
be made into the things
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that make us feel good. Exactly.
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So if you're
diabetic not only do you
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not get the sugar you need
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into you know, the
tissues you need but you also...
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You also don't
make Serotonin right.
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You don't get it into your
brain, you don't feel good.
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Exactly. Interesting,
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so this kind of
raises all ships with those
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and it's a typical treatment
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that you talked about
in Depression recovery
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which is exercise and nutrition
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and you know,
basically learning the truth
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and doing the truth
about these different things.
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That's right. Interesting.
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And actually it can
help better than medicine,
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that's what we've
shown in our studies
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that when you put someone
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on a comprehensive lifestyle
program to treat Depression
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it's better than any
combination of medications
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on the planet in
helping their condition.
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And if people would recognized
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just that alone it
would give them far more hope
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than they have
by paying hundreds
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and sometimes it's
over a $100 a month
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for their antidepressant
medication prescription
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and we need to remind ourselves
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that's the number
one class of drugs
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being given by pharmacist
actually prescribed by doctors
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but passing over the counter
from pharmacist to patient.
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The number one class of drugs
is now antidepressant medicines,
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and
unfortunately they don't work
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near as well as lifestyle.
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So if someone
has major Depression,
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I am not talking
bipolar Depression
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where it's up and
down those swings,
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but if they
have major Depression
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they should really look into
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you know, the same thing that's
gonna help their Depression
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that helps them
address their Diabetes
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in terms of lifestyle things.
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That's right, physical exercise,
sunlight actually helps
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both conditions
omega-3 helps both conditions.
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Proper rest. A plant-based diet.
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That's right, proper rest
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when you're not
getting enough sleep
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you actually are
more insulin resistant.
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And you said also once we
were talking that eating food
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late at night is very bad
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because it
increases you know proper
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It decreases your
melatonin level, yeah,
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decreases your growth hormone;
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those are both
things that are going
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to help your
mental health. Yeah.
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And unfortunately diabetics have
a tenancy to eat late at night
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and not to eat
well in the morning.
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And the best time that
they could actually stimulate
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that food is in
the morning time,
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that's the time when
their insulin receptors
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are gonna work the best.
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So your website still
drnedley.com, right? Correct.
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And that's where you
give more information
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about Depression and
these kind of things. Exactly.
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Let's go into the next
study which I found fascinating,
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was looking at the
waistlines of college students,
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yes, and there is something
called "The Freshman 15,"
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And that Freshman 15
is that when you enter
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into the
freshman year of college
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you may end up
gaining 15 pounds as a result.
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Is that true? Is that a myth?
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Well, it turned
out to be a myth,
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it turned out the
average was five pounds
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and girls entering their
freshman years of college
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And the thing that
Dr. Janis Randall-Simpson
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who conducted this
study said, it was alarming,
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Is this
happened over just to six
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to seven month period of time?
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So they were
gaining five-six pounds
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over six to seven months.
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That's right, and
that's just on average.
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Now that some of
course freshman like lose,
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some might gain like 15,
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but if you just take
an average individual
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who enters college as a female,
their BMI that is there...
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Basal Metabolism, right?
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Well, no it's
actually their density
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as far as... Okay, body mass.
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Body mass index. Index, okay.
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All right, the body mass index
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went from average
of 22 to well over 23,
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and their percent body fat grows
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and the
waistlines also increased
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by two and a half
centimeters or one inch
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in just 6 to 7 months.
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Is this because you're eating
more food they have no work,
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they're not out there
doing things, is that why?
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Well, they're not sure
exactly why it's happening.
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The study just
looked at the averages
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and what was going on
but didn't really address it.
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And I think you know,
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it's really any one's guess
as to why this is taking place?
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But in reality a
lot of cafeterias,
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in fact the study point
at this how we think might,
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some other reasons are
many college cafeterias
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you just pay a fee to eat lunch
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and it's kind
of all you can eat.
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And so people think
they're getting more
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for their money
if they eat more.
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Right, so that adds problems.
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You know, Weimar
College Associated with that
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and also with
Amazing Facts College
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and putting their work
part aspect into the program
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something that
really seems to mitigate
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against
developing those problems.
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We worked and then you study
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and if you're working,
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I mean I wonder why it is
they're gaining so much weight.
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Now one thing I point
out in your study you said
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that it was six to seven months
they gain five to seven pounds
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are something like that.
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Well, if you
extrapolate that 12 months
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it's sounds like it
would be closer to the
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12 or 15 pounds
in the first year.
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Well, and that's true.
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And of course, if you do
that year-after-year, yeah.
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I mean you're
gonna search yourself up
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for some major health issues.
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And that's, and that's
what tends to happen to America,
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I mean they gain
about five pounds every year
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and keep on going.
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I will, little bit more
than I did in college, do you?
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I do, yeah. But
not 15 pounds a year.
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Not 15 pounds a year,
not even five pounds a year.
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Yeah. And you know they,
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you're right work base
programs would be important,
00:10:03.33\00:10:05.97
physical
exercise is very important
00:10:05.98\00:10:08.68
in this whole aspect of things
00:10:08.69\00:10:10.86
as well as choosing proper foods
that are not dense in calories,
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but actually dense in nutrients.
00:10:16.32\00:10:17.98
Nutrient dense low calories,
if we make the right choices
00:10:17.99\00:10:22.20
we can keep these
freshmen as thin as they were
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when they enter
their freshmen year.
00:10:24.26\00:10:25.87
Well, that's good news
00:10:26.74\00:10:28.11
and for those of you
who've gained a few pounds
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I think you know
doing the same things,
00:10:29.91\00:10:31.60
but probably bring you back.
00:10:31.61\00:10:33.01
Red yeast, this was
interesting, what's red yeast?
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Yeah, just one minute
before we go to red yeast,
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the last study for
those that are interested
00:10:39.80\00:10:41.86
it was the Journal of the
American Dietetic Association
00:10:41.87\00:10:46.25
that published that
study in June of 2008.
00:10:46.26\00:10:49.51
Okay, red yeast
tell me what it is,
00:10:49.52\00:10:52.44
why we should be
interested in and all about?
00:10:52.45\00:10:55.44
Well, red yeast is a traditional
Chinese dietary supplement
00:10:55.45\00:10:59.92
and sometimes the active
ingredient is called XZK,
00:10:59.93\00:11:05.39
which stands for
Xuezhikang, a nice Chinese term
00:11:06.00\00:11:10.07
and that's the
derivative of red yeast rice.
00:11:10.08\00:11:13.29
And it, we have
known for a while.
00:11:13.30\00:11:15.88
This is rice, it's not
yeast it's red yeast rice.
00:11:15.89\00:11:18.28
Red yeast rice, correct. Okay.
00:11:18.29\00:11:20.42
And we have known for a
while that this type of rice
00:11:20.43\00:11:24.02
actually does have a tendency
to lower cholesterol levels.
00:11:24.03\00:11:27.63
In fact, you can find
00:11:27.64\00:11:29.26
red yeast rice
extract in pharmacies
00:11:29.82\00:11:35.31
and health food stores
and those type of things.
00:11:35.46\00:11:38.20
And some people use that
is an alternative for taking
00:11:38.21\00:11:40.86
cholesterol lowering medicines.
00:11:40.87\00:11:43.16
The study show they do,
it does lower cholesterol,
00:11:43.17\00:11:46.33
probably not to the extent of
a Lipitor or Zocor or Crestor.
00:11:46.34\00:11:51.35
These are the
cholesterol lower in medicines.
00:11:51.36\00:11:52.88
These are in
cholesterol lower in medicines.
00:11:52.89\00:11:55.27
But you know, the
heartcore physician
00:11:55.28\00:11:58.39
who really wants
to know about outcomes
00:11:58.40\00:12:00.39
is not just interested to know
00:12:00.40\00:12:02.31
whether the
cholesterol goes down
00:12:02.32\00:12:03.98
we think that's helpful,
but the purist will say,
00:12:03.99\00:12:08.16
we don't know if
that's really helpful or not
00:12:08.17\00:12:09.92
unless we've done
outcome studies to show
00:12:09.93\00:12:12.33
that the
individuals actually do better
00:12:12.34\00:12:14.50
who are taking the
medicine or the supplement.
00:12:14.51\00:12:16.86
Of course, it
costs millions of dollars
00:12:16.87\00:12:18.87
to do these prospective
randomized control studies.
00:12:18.88\00:12:22.66
And one of the reasons
why drugs are out there
00:12:22.67\00:12:26.04
and can be sold in mass
00:12:26.05\00:12:27.84
is simply because millions
of dollars have gone into it;
00:12:27.85\00:12:30.86
you don't see
millions of dollars poured
00:12:30.87\00:12:32.71
into red yeast rice extract.
00:12:32.72\00:12:36.72
And do you know the reason, Don?
00:12:36.73\00:12:38.27
That's because
there is no good looking
00:12:38.93\00:12:40.86
pharmaceutical rep that comes
00:12:40.87\00:12:42.22
and talked about red yeast,
00:12:42.23\00:12:43.84
no, not, no Chinese
acrobat that comes in
00:12:43.85\00:12:45.98
and diets into your
office with the rice.
00:12:45.99\00:12:48.93
Well, yes that's and
the reason why they don't?
00:12:48.94\00:12:52.32
Why isn't they're good looking
representatives coming from?
00:12:53.27\00:12:55.71
Probably there is not
00:12:55.72\00:12:56.69
a lot of money out
through this annum.
00:12:56.70\00:12:57.67
That's right, it comes from rice
00:12:57.68\00:12:59.14
and if you try
to pattern this rice
00:12:59.15\00:13:01.72
it will be called
the U.S. Government
00:13:01.73\00:13:04.07
will send you a nice letter bag,
that'll be called Prior Art.
00:13:04.08\00:13:07.18
In other words,
it's already there
00:13:07.19\00:13:09.30
it's been in the
food supply for centuries
00:13:09.31\00:13:11.65
and so you can't patterned that
and if you can't patterned that
00:13:11.66\00:13:14.60
then you don't
have the ability to make
00:13:15.53\00:13:17.15
a lot of money off of it.
00:13:17.16\00:13:18.45
And so a lot of
times supplements
00:13:18.46\00:13:21.31
are prepared by
medical professionals
00:13:21.32\00:13:24.40
as being well there
isn't any evidence for this
00:13:24.41\00:13:26.68
and you know which sure
be nice to see the evidence.
00:13:26.69\00:13:29.33
Well, these
individuals did the study
00:13:29.34\00:13:31.70
and it actually was
published in well places
00:13:31.71\00:13:34.12
the American
Journal of Cardiology.
00:13:34.13\00:13:36.15
Oh, is that right?
00:13:36.16\00:13:37.14
American Journal of
Cardiology June 15, 2008
00:13:37.15\00:13:40.70
and here is their quote,
00:13:40.71\00:13:42.20
"Chinese red yeast
rice is a botanical product
00:13:42.21\00:13:45.44
that has been used in
China for many centuries
00:13:45.45\00:13:47.33
for the treatment of
circulatory disorders.
00:13:47.34\00:13:49.50
The co-author Dr. David Capuzzi
at Thomas Jefferson University
00:13:49.51\00:13:53.50
in Philadelphia noted.
00:13:53.51\00:13:54.64
Particular
preparation used in this study
00:13:55.54\00:13:57.16
has been grown under
carefully control lab record,
00:13:57.17\00:13:59.28
laboratory conditions so that
its components are reproducible.
00:13:59.29\00:14:03.88
And for their study
they recruited four,
00:14:03.89\00:14:06.85
almost 4000 men
and about a 1000 women
00:14:06.86\00:14:10.25
who'd survived a heart attack
and had high cholesterol levels.
00:14:10.26\00:14:13.48
And so this is
the right population
00:14:14.58\00:14:16.51
they've already
had heart disease,
00:14:16.52\00:14:18.21
they already have
high cholesterol levels.
00:14:18.22\00:14:20.62
And now they have the study.
00:14:20.63\00:14:21.60
And they've already
had a high heart attack
00:14:21.61\00:14:24.24
and what they did
is they treated them
00:14:24.25\00:14:26.23
with either the red yeast rice
00:14:26.24\00:14:28.45
or placebo for
four and a half years,
00:14:28.46\00:14:30.67
so it was a prospective study.
00:14:30.68\00:14:32.40
And what they found out is
those on the red yeast rice
00:14:33.17\00:14:36.26
actually had
1.9% of them ended up
00:14:37.56\00:14:40.77
having a follow up heart attack
00:14:40.78\00:14:42.48
within that study period
of four and a half years,
00:14:42.49\00:14:45.40
but those not on it 5%
00:14:45.41\00:14:47.92
and so the difference
was well over double the risk
00:14:47.93\00:14:53.04
if you were not consuming
red yeast rice extract.
00:14:53.05\00:14:58.38
And in fact the group
00:14:58.39\00:15:00.35
that was not consuming
the red yeast rice extract
00:15:00.36\00:15:03.43
over about twice as
many of those needed
00:15:03.44\00:15:06.43
stent procedures later on
and needed those type of things
00:15:06.44\00:15:10.43
and the mortality right
also was lower significantly
00:15:10.44\00:15:13.64
by taking red
yeast rice extract.
00:15:13.65\00:15:16.00
Does it taste good?
00:15:16.01\00:15:17.29
It can, yeah. Rice
can be tasty thing.
00:15:17.30\00:15:21.61
Same as the other couple of
rice because red yeast rice.
00:15:21.62\00:15:22.78
Yeah, and of course
00:15:22.79\00:15:23.76
in this condition they weren't
just feeding them, right,
00:15:23.77\00:15:26.84
the rice they were
taking the extract. Okay.
00:15:26.85\00:15:29.24
That active component
and putting it in a capsule.
00:15:29.25\00:15:31.62
We're talking
with Dr. Neil Nedley,
00:15:31.63\00:15:33.71
join us when we comeback
00:15:33.72\00:15:35.21
and talk about the
placebo effect and exercise
00:15:35.27\00:15:38.75
and many other fascinating
Cutting Edge Studies.
00:15:38.76\00:15:40.86
Join us when we comeback.
00:15:40.87\00:15:42.16