Hello and welcome to Health for a Lifetime. 00:00:49.84\00:00:52.07 I'm your host Don Mackintosh. 00:00:52.10\00:00:53.61 We're glad that you've joined us today. 00:00:53.64\00:00:55.04 We have an exciting topic today. 00:00:55.07\00:00:57.11 We're going to be talking about the Adventist Health Study. 00:00:57.14\00:01:00.06 There's been several studies done. 00:01:00.09\00:01:02.22 Our guest today is familiar with the studies that had been 00:01:02.25\00:01:04.96 done and he's also familiar with the study that is beginning 00:01:04.99\00:01:09.55 right now and is on-going Adventist Health Study 2. 00:01:09.58\00:01:13.78 If you'd like to be involved, and we hope that you will be 00:01:13.81\00:01:16.59 involved in the Adventist Health Study, 00:01:16.62\00:01:18.46 you can go to adventisthealthstudy. org. 00:01:18.49\00:01:21.77 Talking with us today is Dr. Gary Fraser. 00:01:21.80\00:01:24.63 He's a researcher and a cardiologist. 00:01:24.66\00:01:27.00 He has practiced also in internal medicine. 00:01:27.03\00:01:30.54 He's looked at epidemiology and has a masters in Public Health. 00:01:30.57\00:01:34.13 He teaches and practices at Loma Linda but really works with 00:01:34.16\00:01:38.07 an interdisciplinary research team from around the world. 00:01:38.10\00:01:41.99 When you look at Adventist Health Study, 00:01:42.02\00:01:44.29 isn't that right? 00:01:44.32\00:01:45.29 Yes, that's right. 00:01:45.30\00:01:46.70 So you have a board of directors from Harvard and Stanford 00:01:46.73\00:01:49.84 and all these different places and you've gotten some funding 00:01:49.87\00:01:54.08 to continue this Adventist Health Study. 00:01:54.11\00:01:56.97 I just want in this program to review what are the previous 00:01:57.00\00:02:02.65 studies, briefly, and then go into what we're looking 00:02:02.68\00:02:05.69 at in this new study. 00:02:05.72\00:02:06.96 Adventists provide a remarkable opportunity to particularly 00:02:06.99\00:02:12.15 study diet but also other factors in relation to 00:02:12.18\00:02:15.10 risk of chronic disease. 00:02:15.13\00:02:16.44 Mainly because we have a very wide variety of practice 00:02:16.47\00:02:20.27 within our group which a lot of people don't realize. 00:02:20.30\00:02:23.60 The first study of Adventists was way back in 1960. 00:02:23.63\00:02:27.27 We call that The Adventist Mortality Study. 00:02:27.30\00:02:29.15 The second study began in 1974. 00:02:29.18\00:02:31.73 We call it Adventist Health Study 1. 00:02:31.76\00:02:34.00 Most of the results that you will have heard about perhaps, 00:02:34.03\00:02:37.59 of which I've talked about, have come from that 00:02:37.62\00:02:40.81 study in 1974. 00:02:40.85\00:02:42.31 We have well along now, however; a great opportunity, 00:02:42.35\00:02:48.23 an exciting new study that we call Adventist Health Study 2. 00:02:48.26\00:02:51.38 This time we want to enroll 100,000 people from right across 00:02:51.41\00:02:55.11 the United States and also Canada, all Adventists 00:02:55.14\00:02:58.15 and all 30 years of age and over. 00:02:58.18\00:03:00.82 So far we have 86,000 people enrolled which is 00:03:00.85\00:03:05.52 a large number of people - small city. 00:03:05.55\00:03:08.02 So we're well along the way. 00:03:08.05\00:03:09.98 We do need a few more. 00:03:10.01\00:03:11.09 If people want to be involved, and we hope that you do, 00:03:11.12\00:03:16.83 you go to adventisthealthstudy. org 00:03:16.86\00:03:19.91 At the time of this airing it well may be under way, 00:03:19.94\00:03:24.92 the study may be in progress, but you can see what's happening 00:03:24.95\00:03:28.56 with the study and it may be that you're seeing this while 00:03:28.59\00:03:31.35 they still need people. 00:03:31.38\00:03:32.35 So go to the website, contact your local church or conference. 00:03:32.36\00:03:37.95 They all know how to get in touch with the 00:03:37.98\00:03:39.99 Adventist Health Study. 00:03:40.02\00:03:41.00 Be a part of the research. 00:03:41.03\00:03:44.66 Now in the initial study you looked at things like 00:03:44.69\00:03:47.75 heart disease and cancer and you saw that they're 00:03:47.78\00:03:49.96 actually was a real benefit between being a vegetarian 00:03:49.99\00:03:55.45 vs. non-vegetarian. 00:03:55.48\00:03:57.31 Yes, no question about that. 00:03:57.34\00:03:58.92 The Adventist experience is absolutely unique. 00:03:58.95\00:04:01.91 We recently had an article in the National Geographic 00:04:01.94\00:04:05.96 which show that the California Adventists are perhaps some 00:04:05.99\00:04:11.26 of the longest lived people in the world. 00:04:11.29\00:04:12.87 This appears to relate to their lifestyle. 00:04:12.90\00:04:15.50 The data's out there and I think the government 00:04:15.53\00:04:22.42 is involved in funding some of those studies, but it's 00:04:22.45\00:04:25.38 exciting new opportunity is to go to the next level. 00:04:25.41\00:04:29.94 What is it that you're going to be looking at? 00:04:29.97\00:04:32.59 A number of areas, but why is that people should be involved? 00:04:32.62\00:04:36.71 What are you going to look at? 00:04:36.74\00:04:37.71 How will it help? 00:04:37.72\00:04:38.69 Despite the fact that it might seem that we know a lot about 00:04:38.70\00:04:42.88 diet and chronic disease, in fact what we don't know 00:04:42.91\00:04:45.75 far exceeds what we know. 00:04:45.78\00:04:47.47 There's a lot of ifs, maybes, possiblys, and very few 00:04:47.50\00:04:53.62 certainties out there. 00:04:53.65\00:04:55.28 So to get greater certainty with many of these questions 00:04:55.31\00:04:59.83 we need very, very large studies. 00:04:59.86\00:05:01.26 This is why it might seem like a 100,000 people is a little 00:05:01.29\00:05:04.58 excessive but it's really not. 00:05:04.62\00:05:06.18 The particular questions that we got funded on are really three. 00:05:06.22\00:05:12.18 One is the whole question of soy intake and chronic disease. 00:05:12.21\00:05:19.14 Secondly, vitamin D and calcium and sunlight exposure - those 00:05:19.17\00:05:26.07 things are all related. 00:05:26.10\00:05:27.22 It turns out that they probably are related to risk of cancer. 00:05:27.26\00:05:31.28 It's interesting that many people don't realize that. 00:05:31.31\00:05:34.79 And the third thing is some of the fatty acids that are 00:05:34.82\00:05:38.26 different between vegetarians and non-vegetarians. 00:05:38.29\00:05:40.97 Some of these relate to inflammation and that might be 00:05:41.01\00:05:43.65 important for cancer as well. 00:05:43.69\00:05:45.22 Let's go back and talk a little bit about the mechanisms 00:05:45.25\00:05:47.82 that are involved and why it is that they are so interested. 00:05:47.86\00:05:50.61 I guess again the people that say whether or not this is 00:05:50.65\00:05:53.43 something worthy of funding, something worthy to look at, 00:05:53.47\00:05:56.22 are groups from all over the place. 00:05:56.26\00:05:58.10 It's not just people at Loma Linda. 00:05:58.13\00:05:59.90 It's people from Harvard, Stanford, all these different 00:05:59.93\00:06:02.59 places, and they say, "This is a valid question to ask. " 00:06:02.62\00:06:06.11 Yes, that's correct. 00:06:06.14\00:06:07.40 Why is it that they're saying that looking at soy consumption 00:06:07.43\00:06:11.32 as it relates to what you call chronic disease? 00:06:11.35\00:06:13.96 What are the mechanisms that are intriguing them? 00:06:13.99\00:06:17.86 Give us a little more information on that. 00:06:17.89\00:06:20.10 In part I think that these are important because there is such 00:06:20.13\00:06:25.83 a lot of information in the popular press that suggests that 00:06:25.86\00:06:31.08 Americans should be taking isoflavone pills and eating soy 00:06:31.11\00:06:34.62 products for a wide variety of things. 00:06:34.65\00:06:36.90 Yet it turns out the evidence to support that is still somewhat 00:06:36.93\00:06:40.61 insecure. 00:06:40.64\00:06:41.61 So we have potential problems here of a lot of people doing 00:06:41.62\00:06:47.27 something that you don't entirely know how 00:06:47.30\00:06:49.61 beneficial it is. 00:06:49.64\00:06:50.76 The interesting thing is that outside of the Far East 00:06:50.79\00:06:54.63 there is no easily identified population apart from Adventists 00:06:54.66\00:06:58.40 in the United States, particularly, 00:06:58.43\00:06:59.95 who eat lots of soy. 00:06:59.98\00:07:01.22 There have been a number of studies in the Far East 00:07:01.25\00:07:04.55 that look kind of interesting is that people who eat soy may have 00:07:04.58\00:07:08.20 reduced breast cancer, maybe prostate cancer, and it maybe 00:07:08.23\00:07:12.53 that it's different in different times of the life 00:07:12.56\00:07:14.75 that you eat the soy. 00:07:14.78\00:07:16.37 For instance, two studies have indicated that it's maybe the 00:07:16.40\00:07:20.67 soy girls eat in their adolescence that protect them 00:07:20.70\00:07:23.82 from breast cancer in later life. 00:07:23.85\00:07:25.57 That work is largely being done in the Far East. 00:07:25.60\00:07:29.00 The kinds of soy products they eat back there are different 00:07:29.03\00:07:31.92 than the kind of soy products in general that we have 00:07:31.95\00:07:33.91 available here. 00:07:33.94\00:07:34.91 We think that the active principle in all of these 00:07:34.92\00:07:38.27 are isoflavones. 00:07:38.31\00:07:40.02 Those are chemicals which are very interesting 00:07:40.06\00:07:42.75 because they are actually plant estrogens. 00:07:42.79\00:07:45.41 We know that estrogens are particularly important for 00:07:45.45\00:07:48.43 cancers of the breast and they also have a big influence on 00:07:48.46\00:07:51.82 cancers of the prostate, interestingly. 00:07:51.85\00:07:54.11 So plant estrogens is thought may have influence on some 00:07:54.14\00:07:58.07 of these hormonally dependent cancers in interesting ways. 00:07:58.11\00:08:01.41 We already have a little bit of data on Adventists from 00:08:01.44\00:08:04.67 Adventist Health Study 1 that suggests that soy consumption, 00:08:04.70\00:08:08.74 soy milk consumption might reduce the risk of prostate 00:08:08.78\00:08:11.64 cancer. 00:08:11.67\00:08:12.64 But that's only really the beginnings of the evidence. 00:08:12.65\00:08:15.37 We need so much more. 00:08:15.40\00:08:16.48 Particularly in the African American, 00:08:16.52\00:08:18.92 the black Adventist population, prostate cancer 00:08:18.96\00:08:21.74 is such a problem. 00:08:21.78\00:08:23.07 In fact blacks in general, not just Adventists, where the 00:08:23.11\00:08:26.18 risks appear to be about double than the white population. 00:08:26.22\00:08:29.26 We don't know why. 00:08:29.29\00:08:30.26 If we can find some preventative principles in that group, 00:08:30.27\00:08:33.19 it would be a great improvement. 00:08:33.22\00:08:35.58 Especially the African American or it doesn't have to be 00:08:35.62\00:08:40.19 American, the black culture, if you can be involved 00:08:40.22\00:08:43.20 in the study, contact them. 00:08:43.23\00:08:45.71 This is going to be very helpful to look at that. 00:08:45.75\00:08:48.35 So you are going to look at soy consumption. 00:08:48.38\00:08:52.80 How do you go about that? 00:08:52.83\00:08:55.41 You're a researcher, a statistician as well as a 00:08:55.44\00:08:58.94 a cardiologist in internal medicine. 00:08:58.98\00:09:00.76 How do you know for sure that the samples you're getting 00:09:00.80\00:09:04.71 are actually accurate? 00:09:04.75\00:09:06.09 A very good question because trying to find out what 00:09:06.12\00:09:10.43 one person eats let alone a 100,000 people eat, there's a 00:09:10.47\00:09:14.82 tremendous challenge. 00:09:14.86\00:09:16.06 We have put together a large questionnaire. 00:09:16.10\00:09:20.98 Larger than we would like but it's large because it needs 00:09:21.01\00:09:23.41 to be large. 00:09:23.44\00:09:24.41 Then we've done a number of side studies where we've taken 00:09:24.42\00:09:29.13 the results from this questionnaire from smaller 00:09:29.16\00:09:31.73 groups of people and then taken those same people 00:09:31.77\00:09:34.31 and gotten much more detailed information. 00:09:34.34\00:09:37.08 For instance, we've had them tell us 8 times, 00:09:37.12\00:09:39.79 8 different days, on the phone everything they ate. 00:09:39.83\00:09:43.16 And then it looked like people eat a lot of soy on this very 00:09:43.20\00:09:47.67 detailed way of accessing their diet, do they, the same 00:09:47.71\00:09:50.91 people that looked like they had a lot of soy on the 00:09:50.95\00:09:54.12 questionnaire? 00:09:54.15\00:09:55.12 In fact the correlations is good enough that we believe that the 00:09:55.13\00:09:59.23 data we get on the questionnaire are reasonably accurate. 00:09:59.27\00:10:02.83 The other thing we've just done is that we've taken a group 00:10:02.87\00:10:06.40 of about 200 people who gave us an over night urine, some of the 00:10:06.44\00:10:12.15 same people that are involved in the study, and we measured 00:10:12.19\00:10:15.38 the isoflavones, these phytoestrogens in the urine. 00:10:15.41\00:10:17.34 Then that way you know for sure what they have. 00:10:17.37\00:10:19.27 That's right. 00:10:19.30\00:10:20.27 Then we related that to what they told us 00:10:20.28\00:10:21.65 on the questionnaire. 00:10:21.68\00:10:22.65 And again the correlations between those two 00:10:22.68\00:10:24.82 were quite strong. 00:10:24.85\00:10:26.03 Of course you have to be certain that you're getting 00:10:26.07\00:10:31.37 good information. 00:10:31.40\00:10:32.84 What about the sunlight, vitamin D, calcium connection? 00:10:32.88\00:10:37.77 What's the mechanism there? 00:10:37.81\00:10:39.17 Why is it that they are funding that? 00:10:39.20\00:10:41.47 Vitamin D is something which everybody knows prevents 00:10:41.50\00:10:46.21 rickets and osteomyelitis - bone health. 00:10:46.25\00:10:49.56 But it turns out in the last 10 years or so, scientists have 00:10:49.60\00:10:53.76 come to realize that it's a much more interesting substance 00:10:53.79\00:10:57.92 than that. 00:10:57.95\00:10:58.92 It turns out that it's probably got 00:10:58.93\00:11:01.02 anti-inflammatory properties. 00:11:01.06\00:11:02.93 It also helps cells mature and stop dividing in a disorganized 00:11:02.97\00:11:08.27 way, which of course is the characteristic of cancer. 00:11:08.30\00:11:11.76 And so we have some evidence already that vitamin D 00:11:11.79\00:11:15.21 is an anti-cancer principle. 00:11:15.25\00:11:17.13 We have some evidence also that it prevents high blood pressure. 00:11:17.16\00:11:23.14 It probably has some anti-inflammatory capacity 00:11:23.18\00:11:27.12 which helps it prevent even recurring heart disease. 00:11:27.16\00:11:30.43 This is all cutting edge kind of material and the 00:11:30.47\00:11:33.68 evidence is highly suggestive but it's not really secure. 00:11:33.71\00:11:36.13 This is why we get funded to look at this. 00:11:36.16\00:11:38.61 But it's a very, very interesting substance. 00:11:38.65\00:11:42.78 Moreover, probably most Americans are mildly or 00:11:42.81\00:11:46.91 moderately deficient. 00:11:46.94\00:11:48.74 Where does the sunlight come in? 00:11:48.77\00:11:51.39 Most of the vitamin D we get actually comes from 00:11:51.42\00:11:53.79 sun exposure. 00:11:53.83\00:11:55.01 Some of it comes from dairy products that have been 00:11:55.05\00:11:59.15 supplemented with vitamin D and others will come from 00:11:59.18\00:12:03.25 fish, oil of fish, those that eat fish, 00:12:03.28\00:12:04.71 which is really about the only natural product 00:12:04.75\00:12:06.71 that has much vitamin D. 00:12:06.75\00:12:08.04 But we can make all the vitamin D we need in the skin, 00:12:08.08\00:12:11.87 providing we have adequate sun exposure. 00:12:11.90\00:12:14.28 But getting adequate sun exposure in the way that is 00:12:14.32\00:12:18.23 necessary is actually quite difficult. 00:12:18.26\00:12:20.25 It turns out that in latitudes 30 degrees and north is only 00:12:20.28\00:12:24.35 about 3 or 4 months of the year that the sun actually works. 00:12:24.38\00:12:28.41 And moreover, it's only between about 10 a. m. and 3 p. m. 00:12:28.44\00:12:32.43 that it works. 00:12:32.47\00:12:33.44 So there's a lot of people, of course, cover up. 00:12:33.45\00:12:36.66 A lot of people use a lot of sun block. 00:12:36.70\00:12:39.06 And of course there is some point to all that, because too 00:12:39.09\00:12:42.65 much sun exposure is not good for skin health and skin cancer. 00:12:42.68\00:12:46.21 But there's a very happy medium that needs to be struck. 00:12:46.24\00:12:50.59 Unfortunately, many people are not meeting that standard. 00:12:50.62\00:12:54.85 As we talk today 86,000 people that are signed up 00:12:54.88\00:12:59.08 from all over the United States. 00:12:59.11\00:13:01.47 Some of them are to the North and to the South 00:13:01.51\00:13:04.67 of that latitude that you're... 00:13:04.71\00:13:06.11 So you'll be able to take those groups and look at them? 00:13:06.14\00:13:09.78 It will be a very powerful study. 00:13:09.81\00:13:11.20 What about the African American and the melanin in their skin? 00:13:11.24\00:13:15.16 Are you looking closely at that relationship specifically 00:13:15.19\00:13:19.29 for them? 00:13:19.32\00:13:20.29 Very much so. 00:13:20.32\00:13:21.29 We do believe that there's not very much evidence on that 00:13:21.30\00:13:26.51 group yet. 00:13:26.54\00:13:27.51 We're going to provide some of the best evidence that 00:13:27.52\00:13:29.94 probably their vitamin D levels are lower, in fact, 00:13:29.97\00:13:34.59 than Caucasians. 00:13:34.62\00:13:35.63 In fact we've already in a preliminary way done some 00:13:35.66\00:13:38.87 analysis of that sort demonstrated that is the case. 00:13:38.90\00:13:41.98 Interestingly, the bone health of black Americans is, 00:13:42.01\00:13:47.09 if anything, better than white Americans. 00:13:47.12\00:13:49.33 So there's a dissonance there. 00:13:49.37\00:13:50.93 But whether the vitamin D protective qualities on cancer 00:13:50.96\00:13:55.76 and heart disease might still show themselves in the black 00:13:55.80\00:14:00.56 community because of their lower levels of vitamin D remains 00:14:00.59\00:14:03.92 an open possibility. 00:14:03.95\00:14:05.86 We're talking with Dr. Gary Fraser. 00:14:05.89\00:14:08.26 He's the principle researcher at the Adventist Health Study. 00:14:08.30\00:14:11.42 We'd like you to be a part of that. 00:14:11.45\00:14:14.19 I don't know when you'll be watching this but as we make 00:14:14.23\00:14:17.05 the program we definitely need more help and people enlisting 00:14:17.08\00:14:20.87 in this study. 00:14:20.90\00:14:21.87 You can go to adventisthealthstudy. org 00:14:21.88\00:14:24.69 to be a part of that. 00:14:24.73\00:14:25.70 Contact your local Health and Temperance Leader 00:14:25.71\00:14:28.32 in your conference and they can get you contact information. 00:14:28.36\00:14:31.83 When we come back we'll continue talking about the exciting 00:14:31.87\00:14:35.31 opportunity we have in Adventist Health Study 2. 00:14:35.34\00:14:37.84 We hope that you join us. 00:14:37.87\00:14:38.87 Have you found yourself wishing that you could 00:14:40.58\00:14:42.79 shed a few pounds? 00:14:42.82\00:14:43.79 Have you been on a diet for most of your life, 00:14:43.80\00:14:46.32 but not found anything that will really keep the weight off? 00:14:46.36\00:14:49.57 If you've answered yes to any of these questions, then we 00:14:49.61\00:14:52.79 have a solution for you that works. 00:14:52.83\00:14:55.38 Dr. Hans Diehl and Dr. Aileen Ludington 00:14:55.42\00:14:57.74 have written a marvelous booklet called, 00:14:57.78\00:15:00.03 Reversing Obesity Naturally, and we'd like to send it to you 00:15:00.06\00:15:03.66 free of charge. 00:15:03.69\00:15:04.83 Here's a medically sound approach successfully used 00:15:04.86\00:15:07.83 by thousands who are able to eat more 00:15:07.87\00:15:10.02 and loose weight permanently 00:15:10.06\00:15:11.63 without feeling guilty or hungry through lifestyle medicine. 00:15:11.67\00:15:15.24 Dr. Diehl and Dr. Ludington have been featured on 3ABN 00:15:15.28\00:15:18.83 and in this booklet they present a sensible approach to eating, 00:15:18.86\00:15:22.48 nutrition, and lifestyle changes that can help you prevent 00:15:22.51\00:15:25.69 heart disease, diabetes, and even cancer. 00:15:25.73\00:15:28.09 Call or write today for your free copy: 00:15:28.13\00:15:30.46 Welcome back. 00:15:41.78\00:15:42.75 We're talking with Dr. Gary Fraser. 00:15:42.76\00:15:43.97 We're talking about the Adventist Health Study. 00:15:44.01\00:15:46.19 This is an exciting opportunity. 00:15:46.23\00:15:48.91 I hope that you are a part of it already if you're a 00:15:48.95\00:15:51.04 Seventh-day Adventist Christian. 00:15:51.07\00:15:52.53 If not, go to adventisthealthstudy. org 00:15:52.57\00:15:56.29 Dr. Fraser you've been sharing just some fascinating things 00:15:56.33\00:15:59.93 not only about what's been done which really lays the foundation 00:15:59.96\00:16:04.29 for these... 00:16:04.33\00:16:05.30 You wrote a book, published by Oxford, what is it, about 00:16:05.31\00:16:08.58 250-300 studies that have been done on Seventh-day Adventists? 00:16:08.62\00:16:11.87 Yes, published studies. 00:16:11.90\00:16:13.98 So people look at them. 00:16:14.01\00:16:16.02 They are like one of the only vegetarian groups in the 00:16:16.06\00:16:19.49 Western cultures as opposed to maybe the East and then also 00:16:19.52\00:16:24.52 this National Geographic recently was published 00:16:24.56\00:16:27.50 that profiles the Okinawians, Sardinians, and the 00:16:27.53\00:16:30.44 Seventh-day Adventists. 00:16:30.47\00:16:31.49 But the real thing is this exciting opportunity that we 00:16:31.53\00:16:36.10 have now is based on the research that was done 00:16:36.14\00:16:38.30 a number of years ago isn't it? 00:16:38.34\00:16:39.57 Oh, it very much so. 00:16:39.60\00:16:40.71 So this Adventist Health Study 2 we talked in the first half 00:16:40.74\00:16:45.31 about soy consumption and the possible relationship between 00:16:45.34\00:16:49.87 that and chronic diseases like cancer. 00:16:49.91\00:16:51.30 You also talked about sunlight, vitamin D, calcium connection. 00:16:51.34\00:16:58.25 But there's other things that also they are 00:16:58.29\00:17:02.25 wanting to look at. 00:17:02.28\00:17:03.25 One of them is dietary fats. 00:17:03.26\00:17:04.52 What's the mechanism there? 00:17:04.56\00:17:06.20 Why are they looking at that? 00:17:06.24\00:17:07.81 Well, of course vegetarians, are people who trained 00:17:07.85\00:17:11.42 in that direction have a rather different intake of fatty acids 00:17:11.45\00:17:17.79 than non-vegetarians. 00:17:17.82\00:17:19.28 Specifically they have much less of the saturated fat. 00:17:19.32\00:17:23.88 Or turning it over, the non-vegetarians eat much more 00:17:23.92\00:17:28.44 saturated fat. 00:17:28.48\00:17:29.45 That has all kinds of implications for the blood 00:17:29.46\00:17:32.97 cholesterol and heart disease, of course. 00:17:33.00\00:17:35.17 But it probably also has some implications for cancer risks. 00:17:35.21\00:17:39.64 Also, the meat and dairy products contain a particular 00:17:39.68\00:17:45.37 long chain unsaturated fatty acid called arachidonic acid. 00:17:45.40\00:17:51.06 That turns out to be the pre-cursor of a whole slew 00:17:51.09\00:17:55.30 of chemicals in the body that tend towards promoting 00:17:55.33\00:17:59.50 inflammation in the system. 00:17:59.54\00:18:01.31 So that maybe important as well. 00:18:01.34\00:18:03.79 As I said before, this is on the edge of the research 00:18:03.82\00:18:07.32 somewhat and these are interesting ideas that still 00:18:07.35\00:18:10.81 need to be explored further. 00:18:10.84\00:18:12.15 But on animals and laboratory works this is how it looks. 00:18:12.19\00:18:15.85 There's another array of chemicals that tend to be 00:18:15.88\00:18:20.87 anti-inflammatory that are based on a different set of 00:18:20.90\00:18:25.86 fatty acids that are based on linolenic and some of the fats 00:18:25.89\00:18:30.47 that we find in oily fish. 00:18:30.51\00:18:33.62 So there are these two families of fatty acids and the products 00:18:33.65\00:18:39.11 that they produce that are found in very different 00:18:39.14\00:18:42.48 proportions among vegetarians and non-vegetarians. 00:18:42.52\00:18:45.79 And probably are important for both heart disease and certain 00:18:45.82\00:18:50.28 cancers because inflammation plays an causal role in both 00:18:50.31\00:18:54.73 of these. 00:18:54.77\00:18:55.74 For instance, cancer of the prostate and cancer of the colon 00:18:55.75\00:18:58.57 and probably some of the others. 00:18:58.60\00:19:00.04 So this inflammation process sets people up for the cancer 00:19:00.07\00:19:04.32 which is related to the fatty acids is basically what 00:19:04.36\00:19:08.06 you're saying - one of those two chains? 00:19:08.09\00:19:10.07 Yes, that seems to be the case particularly in animal work and 00:19:10.10\00:19:13.81 laboratory work and also some preliminary work 00:19:13.84\00:19:17.86 in whole people. 00:19:17.89\00:19:18.97 But we need to build on that. 00:19:19.01\00:19:20.99 This is how research is done. 00:19:21.03\00:19:22.94 You've got the National Institute of Health. 00:19:22.97\00:19:24.90 You've got all those different boards and it's very competitive 00:19:24.93\00:19:27.57 as fundings kind of evaporates. 00:19:27.60\00:19:30.55 You told me it's something like 12% of proposals that are sent 00:19:30.59\00:19:34.53 get funded. 00:19:34.57\00:19:35.54 But when they look at it they say, "What's been happening 00:19:35.55\00:19:38.38 in the animal studies, why is it we should give you the funding?" 00:19:38.42\00:19:42.72 That's the essence of it. 00:19:42.76\00:19:45.40 In fact I just put together another application for our 00:19:45.43\00:19:48.10 next 5 years. 00:19:48.13\00:19:49.10 You are faced with the problem, or the challenge I should say, 00:19:49.11\00:19:53.24 of putting together a compelling story that this is something 00:19:53.28\00:19:57.48 that really needs to be done and moreover you can do 00:19:57.51\00:20:00.25 it better than anyone else. 00:20:00.29\00:20:01.32 This proposal you're putting together is actually 00:20:01.36\00:20:05.41 going the next step not just questionnaires but actually have 00:20:05.45\00:20:09.06 blood samples that are drawn and different things among 00:20:09.10\00:20:14.03 church groups in the churches around the country. 00:20:14.07\00:20:17.28 Yes, we have one of the first studies that's right across 00:20:17.31\00:20:21.91 the nation and also Canada. 00:20:21.94\00:20:23.81 As you pointed out that's got this big range of latitude 00:20:23.84\00:20:27.77 but it's also got other advantages but challenges 00:20:27.80\00:20:31.68 as well because think about the problem of getting blood 00:20:31.72\00:20:35.56 from perhaps 50-60,000 people, we won't get it from everybody. 00:20:35.60\00:20:39.17 Scattered across that geographical range we plan to 00:20:39.20\00:20:43.34 conduct clinics in perhaps 3,000 plus churches. 00:20:43.37\00:20:46.51 Well, you know there is always Federal Express or these other 00:20:46.54\00:20:50.27 things now today. - laughter - 00:20:50.31\00:20:51.41 Maybe you'll have some kind of centralized lab or something. 00:20:51.44\00:20:55.70 Now another thing you're looking at is genetics and how they may 00:20:55.74\00:20:59.97 modify results from what we eat or don't eat or what we 00:21:00.00\00:21:05.48 do or don't do. 00:21:05.52\00:21:06.49 Yes, this is becoming very much in the fore of research 00:21:06.50\00:21:12.14 of this sort today. 00:21:12.17\00:21:13.85 One can really not do research on diet without taking into 00:21:13.88\00:21:17.11 account the fact that people are genetically different. 00:21:17.14\00:21:20.33 What we mean by that is that they metabolize 00:21:20.37\00:21:23.21 foods in different ways. 00:21:23.24\00:21:24.52 So even though we may feel that eating tomatoes is protective 00:21:24.56\00:21:28.28 against ovarian cancer in general, that might hide 00:21:28.31\00:21:31.68 the fact that there is a certain sub group of woman that get 00:21:31.72\00:21:35.04 tremendous advantage from eating tomatoes and another 00:21:35.07\00:21:37.78 sub group who get no advantage. 00:21:37.82\00:21:38.99 So on average it looks like a moderate advantage. 00:21:39.02\00:21:42.43 But it would be so much better if we could identify the people 00:21:42.46\00:21:46.01 that got the huge advantage and focus on them rather than 00:21:46.05\00:21:48.97 wasting our efforts on those that don't get any advantage 00:21:49.01\00:21:51.90 from eating tomatoes. 00:21:51.93\00:21:52.90 For instance, that's just an example. 00:21:52.91\00:21:54.19 This is one of the reasons that we would like to get the blood 00:21:54.23\00:22:00.36 that we talked about before. 00:22:00.39\00:22:01.90 We can then divide our population up into people who 00:22:01.94\00:22:05.79 are metabolically different and see if we can find those 00:22:05.82\00:22:09.35 sub groups who are responders and non-responders to these 00:22:09.38\00:22:12.87 different foods. 00:22:12.91\00:22:14.14 A quick question. 00:22:14.18\00:22:15.34 You are a cardiologist. 00:22:15.38\00:22:16.35 I want to ask this. 00:22:16.36\00:22:17.33 Speaking of genetics, we have people that go through 00:22:17.34\00:22:19.92 health programs we've held at our church over the last 00:22:19.96\00:22:23.08 few years - coronary health improvement program, the CHIP 00:22:23.12\00:22:26.21 program that Hans Diehl originated and we take a 00:22:26.25\00:22:28.46 blood sample at the beginning and at the end. 00:22:28.50\00:22:31.80 We have people that are Seventh-day Adventists 00:22:31.83\00:22:35.07 that have really been vegans, I guess you'd say, and some of 00:22:35.10\00:22:39.92 them will just have a really high cholesterol and they're 00:22:39.96\00:22:44.75 not eating any animal products. 00:22:44.78\00:22:47.03 What are the genetics with that? 00:22:47.07\00:22:49.29 Is that a genetic thing? 00:22:49.32\00:22:50.94 There is a lot of genetics. 00:22:50.98\00:22:52.52 Probably the genetic determinates about cholesterol 00:22:52.56\00:22:56.27 is stronger than the dietary on average. 00:22:56.31\00:22:59.54 I've had exactly the same experience as you. 00:22:59.57\00:23:02.73 I run the lypic clinic at Loma Linda University and I have 00:23:02.77\00:23:05.75 vegetarians who are totally confused by the fact that their 00:23:05.78\00:23:08.73 cholesterol is higher than they think it should be. 00:23:08.77\00:23:11.57 Now that means that whatever your genes are, however, you 00:23:11.60\00:23:16.61 still get benefit from having an appropriate diet. 00:23:16.65\00:23:19.67 If my cholesterol was now 250 because I have some genes that 00:23:19.70\00:23:24.94 are not so good, if I didn't have an appropriate diet 00:23:24.98\00:23:27.57 they would probably be 300. 00:23:27.60\00:23:28.61 So it's always worth while living properly but there are 00:23:28.65\00:23:32.76 that group of people who will probably need medications in 00:23:32.79\00:23:36.51 addition to get them down to the levels we now know are 00:23:36.55\00:23:40.23 ideal. 00:23:40.27\00:23:41.24 So in other words, just because it's genetic and it wasn't 00:23:41.25\00:23:44.19 anything you did wrong, it's still not something to ignore. 00:23:44.22\00:23:47.23 If you have cholesterol that's elevated you need to get 00:23:47.26\00:23:50.23 it down. 00:23:50.27\00:23:51.24 Oh, very much so, that's the case, yes. 00:23:51.25\00:23:53.18 Ok, so we've talked about the opportunity we have with 00:23:53.21\00:23:56.94 Adventist Health Study 2, building on what's happened with 00:23:56.98\00:24:00.68 Adventist Health Study 1. 00:24:00.71\00:24:02.12 One other thing, and I want to bring it up in this segment 00:24:02.15\00:24:05.21 as well, is you're going to look at religion and religiosity as 00:24:05.25\00:24:10.80 it relates to mortality. 00:24:10.84\00:24:12.05 Talk with us a little bit about that. 00:24:12.08\00:24:13.92 Initially it started off that people noticed that 00:24:13.95\00:24:17.45 Seventh-day Adventists and Latter Day Saints and 00:24:17.48\00:24:20.91 some others had some differences in their health experience. 00:24:20.95\00:24:23.63 So that's kind of a denominational identifier. 00:24:23.67\00:24:27.10 Then people got to looking at church attendance, 00:24:27.13\00:24:30.49 many different denominations and found that the people 00:24:30.52\00:24:34.09 attended church more regularly had a lower risk of mortality 00:24:34.13\00:24:38.56 and in particular coronary heart mortality. 00:24:38.59\00:24:40.44 Then got to thinking that it probably just wasn't attendance 00:24:40.47\00:24:44.47 that was important. 00:24:44.50\00:24:45.84 So what could it be? 00:24:45.87\00:24:47.13 It was probably something much more subtle than that. 00:24:47.17\00:24:51.40 It may be several things. 00:24:51.44\00:24:52.61 There's usually not just one factor in these. 00:24:52.65\00:24:54.23 Religion can have... it can interface with your life in 00:24:54.26\00:24:59.35 many, many different ways and provide potential protection 00:24:59.39\00:25:04.44 and also for harm, actually. 00:25:04.47\00:25:05.78 So we need to dig a lot deeper than that. 00:25:05.81\00:25:09.51 We're interested in things like prayer life, attitudes to prayer 00:25:09.55\00:25:13.46 amongst Adventist, but not only Adventist, the Sabbath day, 00:25:13.49\00:25:17.35 and the concept of the Sabbath day rest. 00:25:17.39\00:25:19.40 Many people will interpret the Sabbath in a very different way 00:25:19.44\00:25:24.98 to others. 00:25:25.02\00:25:25.99 Some will go out and do all kinds of activities in nature 00:25:26.00\00:25:32.77 others take it very literally as a rest. 00:25:32.80\00:25:35.29 Others see it as a burden, wishing they were able 00:25:35.33\00:25:37.96 to do something else. 00:25:38.00\00:25:38.97 So you're going to be looking at those? 00:25:38.98\00:25:41.87 Exactly. 00:25:41.91\00:25:42.88 That will be fascinating. 00:25:42.91\00:25:45.49 I think this will be applicable to not just to 00:25:45.53\00:25:48.09 Seventh-day Adventists, of course, but we'll learn 00:25:48.13\00:25:50.66 lessons for just about everybody. 00:25:50.70\00:25:52.23 Yes, and that's of course we got funded because 00:25:52.27\00:25:54.81 we could make the point that Adventist have many things in 00:25:54.84\00:25:58.10 common with many other denominations. 00:25:58.14\00:25:59.58 What we would learn amongst Adventists, with the great 00:25:59.61\00:26:02.23 variety that we have of practice and belief will be applicable 00:26:02.26\00:26:05.84 in a broader sense. 00:26:05.87\00:26:07.17 Now, I don't want to put you on the spot or anything, 00:26:07.21\00:26:09.39 but you're a researcher from Loma Linda University, you've 00:26:09.42\00:26:12.67 been a Seventh-day Adventist a number of years. 00:26:12.71\00:26:16.42 The writings of Ellen White, sometimes people respond in 00:26:16.45\00:26:20.91 different ways to those, but as a researcher over the last 00:26:20.94\00:26:24.67 30 years, do you have more or less confidence in Ellen White 00:26:24.71\00:26:28.40 as you're coming through this research? 00:26:28.44\00:26:29.93 Oh I think the advice that she gave the church on health has 00:26:29.96\00:26:35.97 been just a marvelous benefit. 00:26:36.01\00:26:37.91 Here we are as a group that have had for 140 years 00:26:37.94\00:26:44.23 in her writings information which the general population 00:26:44.26\00:26:49.04 has really only had, or only getting now, or certainly not 00:26:49.08\00:26:53.82 had for more than 10 or 15 years. 00:26:53.86\00:26:55.06 I see in Adventism this being a gift which is our 00:26:55.09\00:26:59.66 responsibility to give to our neighbors and friends 00:26:59.69\00:27:03.07 to the world, not something to keep to ourselves. 00:27:03.10\00:27:06.48 Thank you so much, Dr. Fraser, for what you do 00:27:06.52\00:27:09.83 in research and for what you're doing at Loma Linda 00:27:09.86\00:27:12.97 and spearheading this. 00:27:13.01\00:27:14.60 The Lord has really gifted you to be in that position. 00:27:14.64\00:27:17.48 I know you take it seriously. 00:27:17.52\00:27:18.65 Thank you for what you do. 00:27:18.68\00:27:19.75 Thank you for being with us today. 00:27:19.78\00:27:21.21 Thank you for the invitation. 00:27:21.25\00:27:22.54 Thank you for joining us today on Health for a Lifetime. 00:27:22.57\00:27:25.71 If you have not become a part of the Adventist Health Study, 00:27:25.74\00:27:28.84 I think that Dr. will agree with me, please sign up now 00:27:28.88\00:27:31.91 especially if you're an African American, but no matter 00:27:31.94\00:27:35.82 what you are continue to be involved in the process. 00:27:35.85\00:27:39.66 adventisthealthstudy. org is where you would go to sign up 00:27:39.70\00:27:44.73 or you can contact the people in your local 00:27:44.77\00:27:46.77 church or conference. 00:27:46.80\00:27:47.88 This research that's done today can help not only you but it can 00:27:47.92\00:27:53.27 help many other people. 00:27:53.31\00:27:54.83 So take it serious and thank you for joining us. 00:27:54.86\00:27:57.57